ID A0A2Y9R267_TRIMA Unreviewed; 651 AA.
AC A0A2Y9R267;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=MBT domain-containing protein 1 isoform X4 {ECO:0000313|RefSeq:XP_023588512.1};
GN Name=LOC101348095 {ECO:0000313|RefSeq:XP_023588512.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023588512.1};
RN [1] {ECO:0000313|RefSeq:XP_023588512.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_023588512.1; XM_023732744.1.
DR AlphaFoldDB; A0A2Y9R267; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20120; MBT_MBTD1_rpt1; 1.
DR CDD; cd20123; MBT_MBTD1_rpt2; 1.
DR CDD; cd20126; MBT_MBTD1_rpt3; 1.
DR CDD; cd20129; MBT_MBTD1_rpt4; 1.
DR Gene3D; 2.30.30.140; -; 4.
DR Gene3D; 3.30.60.160; -; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR012313; Znf_FCS.
DR InterPro; IPR038603; Znf_FCS_sf.
DR PANTHER; PTHR12247:SF79; MBT DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR Pfam; PF02820; MBT; 4.
DR Pfam; PF21319; zf-FCS_1; 1.
DR SMART; SM00561; MBT; 4.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 4.
DR PROSITE; PS51079; MBT; 4.
DR PROSITE; PS51024; ZF_FCS; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00367}.
FT DOMAIN 68..103
FT /note="FCS-type"
FT /evidence="ECO:0000259|PROSITE:PS51024"
FT REPEAT 164..268
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 276..372
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 374..479
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 487..583
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 73283 MW; EE3630E017D86653 CRC64;
MENTKDLTEH SSRPERKRRD SFGMFDGYDS CSEDTSSSSS SEESEEEVAP LPSNLPIIKN
NGQVYTYPDG KSGMATCEMC GMVGVRDAFY SKTKRFCSVS CSRSYSSNSK KASILARLQG
KPPTKKAKVL QKQPLVAKLA AYAQYQATLQ NQAKTKAAVS MEGFSWGNYI NSNSFIAAPV
TCFKHAPMGT CWGDISENVR IEVPNTDCSL PTKVFWIAGI VKLAGYNALL RYEGFENDSG
LDFWCNICGS DIHPVGWCAA SGKPLVPPRT IQHKYTNWKA FLVKRLTGAK TLPPDFSQKV
SESMQYPFKT CMRVEVVDKR HLCRTRVAVV ESVIGGRLRL VYEESEDRTD DFWCHMHSPL
IHHIGWSRSI GHRFKRSDIT KKQDGHFDTP PHLFAKVKEV DQSGEWFKEG MKLEAIDPLN
LSTICVATIR KVLADGFLMI GIDGSEAADG SDWFCYHATS PSIFPVGFCE INMIELTPPR
GYTKLPFKWF DYLRETGSIA APVKLFNKDV PNHGFRVGMK LEAVDLMEPR LICVATVTRI
IHRLLRIHFD GWEEEYDQWV DCESPDLYPV GWCQLTGYQL QPPASQSSRE SQSGSSKQKK
KAKSQQYKGH KKMTTLQLKE ELLDGEDYNF LQGASDQESN GSANFYIKQE P
//
