ID A0A2Y9R2A2_TRIMA Unreviewed; 656 AA.
AC A0A2Y9R2A2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Actin-binding LIM protein 1 isoform X8 {ECO:0000313|RefSeq:XP_023585743.1};
GN Name=LOC101347995 {ECO:0000313|RefSeq:XP_023585743.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023585743.1};
RN [1] {ECO:0000313|RefSeq:XP_023585743.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_023585743.1; XM_023729975.1.
DR AlphaFoldDB; A0A2Y9R2A2; -.
DR STRING; 127582.A0A2Y9R2A2; -.
DR InParanoid; A0A2Y9R2A2; -.
DR OrthoDB; 370973at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR CDD; cd09328; LIM2_abLIM; 1.
DR CDD; cd09329; LIM3_abLIM; 1.
DR CDD; cd09330; LIM4_abLIM; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR032402; AbLIM_anchor.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24213; ACTIN-BINDING LIM PROTEIN; 1.
DR PANTHER; PTHR24213:SF18; ACTIN-BINDING LIM PROTEIN 1; 1.
DR Pfam; PF16182; AbLIM_anchor; 1.
DR Pfam; PF00412; LIM; 3.
DR Pfam; PF02209; VHP; 1.
DR SMART; SM00132; LIM; 3.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 5.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR PROSITE; PS51089; HP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 4..64
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 72..131
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 588..656
FT /note="HP"
FT /evidence="ECO:0000259|PROSITE:PS51089"
FT REGION 217..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 656 AA; 73878 MW; 4EA03368BE034466 CRC64;
MYGTCCHGCG EFVEGEVVTA LGKTYHPNCF ACTICKRPFP PGDRVTFNGR DCLCQLCAQP
MSSSPKEATC SSNCAGCGRD IKNGQALLAL DKQWHLGCFK CKSCGKVLTG EYISKDGAPY
CEKDYQGLFG VKCEACHQFI TGKVLEAGDK HYHPSCARCS RCNQMFTEGE EMYLQGSTVW
HPDCKQSTKT EEKLRPPNLH RSSFDFFYPK SLIRRAGRSS SLQPTRTSSE SIYSRPGSSI
PGSPGHTIYA KVDNEILDYK DLAAIPKVKA IYDIERPDLI TYEPFYTSGY DDKQERQSLG
ESPRTLSPTP SAEGYQDVRD RMIHRSTSQG SINSPVYSRH SYTPTTSRSP QHFHRPGNEP
SSGRNSPLPY RPDSRPLTPT YAQAPKHFHV PDQGINIYRK PPIYKQHDAA ALAAQSKSSE
DIIKFSKFPA AQAPDHNEIP KIETDLWPGP PSVATIGTDM RRRSSGREED EEELLRRRQL
QEEQLMKLNS GLGQLILKEE MEKESRERAS LSASRYDSPI NSASHAPSSK TSSLPGYGKN
GLHRPVSTEF AQYNSYGDVS GGVRDYQTLP DGHMPGMRMD RGVSMPNMLE PKIFPYEMLM
VTNRGRNKIL RDVDRTRLER HLSPEVFREI FGMSIQEFDR LPLWRRNDMK KKAKLF
//
