ID A0A2Y9R3X7_TRIMA Unreviewed; 491 AA.
AC A0A2Y9R3X7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Metal-response element-binding transcription factor 2 isoform X4 {ECO:0000313|RefSeq:XP_004378805.1, ECO:0000313|RefSeq:XP_023589212.1};
GN Name=LOC101344546 {ECO:0000313|RefSeq:XP_004378805.1,
GN ECO:0000313|RefSeq:XP_023589212.1, ECO:0000313|RefSeq:XP_023589213.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023589212.1};
RN [1] {ECO:0000313|RefSeq:XP_004378805.1, ECO:0000313|RefSeq:XP_023589212.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_004378804.1; XM_004378747.1.
DR RefSeq; XP_004378805.1; XM_004378748.2.
DR RefSeq; XP_004378806.1; XM_004378749.1.
DR RefSeq; XP_023589212.1; XM_023733444.1.
DR RefSeq; XP_023589213.1; XM_023733445.1.
DR GeneID; 101344546; -.
DR OrthoDB; 5483634at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15578; PHD1_MTF2; 1.
DR CDD; cd15580; PHD2_MTF2; 1.
DR Gene3D; 3.90.980.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR025894; Mtf2_C_dom.
DR InterPro; IPR042014; MTF2_PHD1.
DR InterPro; IPR042015; MTF2_PHD2.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12628:SF12; METAL-RESPONSE ELEMENT-BINDING TRANSCRIPTION FACTOR 2; 1.
DR PANTHER; PTHR12628; POLYCOMB-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF14061; Mtf2_C; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS01359; ZF_PHD_1; 2.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 1..55
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 260..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 55768 MW; 117A25BF93579232 CRC64;
MVCTICQEEY SEAPNEMVIC DKCGQGYHQL CHTPHIDSSV IDSDEKWLCR QCVFATTTKR
GGALKKGPNA KALQVMKQTL PYSVADLEWD AGHKTNVQQC YCYCGGPGDW YLKMLQCCKC
KQWFHEACVQ CLQKPMLFGD RFYTFICSVC SSGPEYLKRL PLQWVDIAHL CLYNLSVIHK
KKYFDSELEL MTYINENWDR LHPGELADTP KSERYEHVLE ALNDYKTMFM SGKEIKKKKH
LFGLRIRVPP VPPNVAFKAE KEPEGTSHEF KIKGRKASKP ISDSREVSNG LEKKGKKKSV
GRPPGPYTRK MIQKTAEPPL DKESISENPT LDLPCSIGRT EGTAHSSNTS DVDFTGASTA
KETTSSSISR HYELSDSRKR TRTGRSWPAA IPHLRRRRGR LPRRALQTQN SEIVKDDEGK
EDYQFDELNT EILNSLADQE LQLNHLKNSI TSYFGAAGRI ACGEKYRVLA RRVTLDGKVQ
YLVEWEGATA S
//
