ID A0A2Y9R410_TRIMA Unreviewed; 1036 AA.
AC A0A2Y9R410;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transcription factor Dp-1 isoform X1 {ECO:0000313|RefSeq:XP_023589247.1};
GN Name=LOC101350765 {ECO:0000313|RefSeq:XP_023589247.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023589247.1};
RN [1] {ECO:0000313|RefSeq:XP_023589247.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR RefSeq; XP_023589247.1; XM_023733479.1.
DR AlphaFoldDB; A0A2Y9R410; -.
DR STRING; 127582.A0A2Y9R410; -.
DR InParanoid; A0A2Y9R410; -.
DR OrthoDB; 1362879at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd14458; DP_DD; 1.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 1.20.140.80; Transcription factor DP; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR045158; KEA4/5/6-like.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR038168; TF_DP_C_sf.
DR InterPro; IPR014889; Transc_factor_DP_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR16254; POTASSIUM/PROTON ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR16254:SF30; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF08781; DP; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR SMART; SM01138; DP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|RuleBase:RU003796};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|RuleBase:RU003796};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1036
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015846749"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 737..819
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 826..971
FT /note="Transcription factor DP C-terminal"
FT /evidence="ECO:0000259|SMART:SM01138"
FT REGION 705..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 125..204
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 705..728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1036
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1036 AA; 116052 MW; C3A559A820104DAA CRC64;
MKVLGKTNLW ILFSLLHLIA NAAEHEEVAK HAIKLHRGKG AAIAQRKHWV LENCRKLSGL
LRQKNVVLNK LKNAIRAVEK DVGLSDEEKL FQVHTFEIFQ KELNESENSV FQAIHGLQRA
LQGDYKDVVN MKESSRQRLE ALREAAIKEE TEYVELLAAE KHQVEALKNM QHQNKSLSIL
DEILEDVRKA ADRLEEEIEE HAFDDNKSVK GVNFEAVLRV EEEEANSKKN ITKREVEDDL
GLSMLIDSQN NQYILTKPRD STIPRADHHF IKDIVTIGML SLPCGWLCTT IGLPTMFGYI
ICGVLLGPSG LNSIKSIVQV ETLGEFGVFF TLFLVGLEFS PEKLRKVWKI SLQGPCYMTL
LMIGFGLLWG HFLQIRATQS VFISTCLSLS STPLVSRFLV GSARGDKEGD IDYSTVLLGM
LVMQDVQLGL FIAVMPTLIQ AGAGTYSSIF MEILRILVLI GQILFSLAAV FLLCLVIKTY
LMGPYYRKLH MESKGNKEIL ILGISAFIFI MLTITELLDV SMELGCFLAG ALISSQGHMV
TEEIMSYIEP IRDFLAIIFF ASIEKSLFLL WRVNIYRIDF TDLVTWQKIT SKTHLLKSEF
FLEKIQKNKK RIKKSPVISK PRDKLFVTFS ASLIEANGEL KVFIDQNLSP GKGVVSLVAV
HPSTVNTLGK QLLPKTFGQS NVNIAQQVVI GTPQRPAAPN TILVGSPHTP NTHFVSQNQA
SDSSPWSAGK RNRKGEKNGK GLRHFSMKVC EKVQRKGTTS YNEVADELVA EFSAADNHIL
PNESAYDQKN IRRRVYDALN VLMAMNIISK EKKEIKWIGL PTNSAQECQN LEVERQRRLE
RIKQKQSQLQ ELILQQIAFK NLVQRNRQAE QQANRPPPSN SVIHLPFIIV NTSKKTVIDC
SISNDKFEYL FNFDNTFEIH DDIEVLKRMG MACGLESGSC SAEDLKMARS LVPKALEPYV
TEMAQGSISG VFVTSSGSTS NGTRLSASDL TNGADGMLAT SSNGSQYSGS RVETPVSYVG
EDDDDDDDFN ENDDED
//
