ID A0A2Y9R615_TRIMA Unreviewed; 571 AA.
AC A0A2Y9R615;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Muellerian-inhibiting factor {ECO:0000256|ARBA:ARBA00020473};
DE AltName: Full=Anti-Muellerian hormone {ECO:0000256|ARBA:ARBA00030008};
DE AltName: Full=Muellerian-inhibiting substance {ECO:0000256|ARBA:ARBA00031273};
GN Name=LOC101340301 {ECO:0000313|RefSeq:XP_023588921.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023588921.1};
RN [1] {ECO:0000313|RefSeq:XP_023588921.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_023588921.1; XM_023733153.1.
DR STRING; 127582.A0A2Y9R615; -.
DR KEGG; tmu:101340301; -.
DR InParanoid; A0A2Y9R615; -.
DR OrthoDB; 3972567at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR CDD; cd13757; TGF_beta_AMH; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006799; AMH_N.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR021203; Muellerian-inhibiting_factor.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR15009; MUELLERIAN-INHIBITING FACTOR; 1.
DR PANTHER; PTHR15009:SF4; MUELLERIAN-INHIBITING FACTOR; 1.
DR Pfam; PF04709; AMH_N; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Gonadal differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..571
FT /note="Muellerian-inhibiting factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015986929"
FT DOMAIN 453..571
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 272..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 60253 MW; 0CB691131833DD39 CRC64;
MPASPPLPHL ALVLAALGAA LGAGTPRQEA LSTPALSKEI ASGPRGLIFS EDWAWPLPDS
PGDPLCLVTL GGGGNGSGAP FRVVGALGSY EQAFLEAVYR ARWGARDLAT FGLCAPGEGQ
AALALLQQLG AWLRQPGGQH LVVLHLEEVT WEPTPSLRFQ EPPPGGAGPL DPALLVLYPG
TGPAATITGA GLPGAQGLCP SQNTRYLVLA VEHPEDAWRS SGLTLTLRPP GDSAPLGTAQ
LQALLFGADP RCFTRMTPAL LLLPRPRPTP LPAQGSLDLV PFPWPRPSPQ PEAPRGADPF
LETLTRLVRA LRGPRSRVSP PRLTLDPGAL AAFPQGLVNL SDPAALKRLL DGEEPLLLLR
PLPASDAAGD VASVPDPTGE APWAAVLARR VAAELQAAAA ELQGLPXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXQGLRAEW RWRERRERPQ RSAGVAPGGD GPCALRELSV
DLRAESSVLI PETYQANNCQ GACGWPQSDR NPHYGNHVVL LLKMQARGAA LARPPCCVPT
AYAGKVLISL SEERISAHHV PNMVATECGC R
//
