ID A0A2Y9R7J7_TRIMA Unreviewed; 1507 AA.
AC A0A2Y9R7J7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=P-type Cu(+) transporter {ECO:0000256|ARBA:ARBA00012517};
DE EC=7.2.2.8 {ECO:0000256|ARBA:ARBA00012517};
GN Name=LOC101347172 {ECO:0000313|RefSeq:XP_023589386.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023589386.1};
RN [1] {ECO:0000313|RefSeq:XP_023589386.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
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DR RefSeq; XP_023589386.1; XM_023733618.1.
DR STRING; 127582.A0A2Y9R7J7; -.
DR KEGG; tmu:101347172; -.
DR InParanoid; A0A2Y9R7J7; -.
DR OrthoDB; 5480493at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0140581; F:P-type monovalent copper transporter activity; IEA:UniProtKB-EC.
DR CDD; cd00371; HMA; 6.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 6.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006122; HMA_Cu_ion-bd.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR NCBIfam; TIGR00003; copper ion binding protein; 6.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 6.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00942; CUATPASEI.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 6.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 6.
DR PROSITE; PS50846; HMA_2; 7.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT TRANSMEM 662..681
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 717..740
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 752..777
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 783..805
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 948..972
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 992..1015
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1367..1389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1395..1415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 16..82
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 93..159
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 179..245
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 285..351
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 385..451
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 496..562
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 572..638
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 1507 AA; 164244 MW; 09325A6A047BA403 CRC64;
MECKEEVKMN PSMHMNSAII SVEGMTCSSC VWTIEQQIGK MNGVHHIKVS LEEKNATVVY
NPKLQTPKTL QDAINDMGFD ATLHNPNPLP VLTDSVFLSV SSSFAPPWDH IQSTLLKTKG
VTDIKISPQQ RTAVVTIIPS IVNANQIIEL VPGVSLDTGT LEKKSGTCED YSMAQGGEIM
LKMKVEGMTC HSCTSTIEGK IGKLQGVQRI KVSLENQEAT VVYQPHLITV EEIKKQIEAV
GFSVFIKKQP KYLTLGAIDI ERLKNTPVRS SEGSEQRSPS YTNDSTATFI INGMHCKSCV
SNIESALSTL QYVSSIAISL ENRSANVKYN ASLVTPETLR KTIEAISPGQ YSVSITSDAE
STPSSPSSSY HQKIPLNIVS QPLTQETVIN IGGMTCNSCV QSIEGVISKK AGVKSIQVSL
VNSSGIIEYD PLLNSPETLR EAIENMGFDA ALSDVNEPSV LITQPSSEMP LLASANEFYA
KIMTPVHDKE ETRTSSKCYI QVTGMTCASC VANIERNLRR EEGIYSVLVA LMAGKAEVRY
NPAVIQPPMI AEFIRELGFG ATVIENADEG DGILELVVRG MTCASCVHKI ESTLTKHRGI
FYCSVALATN KAHIKYDPEI IGPRDIIHTI ESLGFEASLV KKDRSASHLD HKREIRQWRR
SFLVSLFFCI PVMGLMIYMM VMDHHLAALH HNQNMSQEEM INIHSSMFLE HQILPGLSIM
NLLSFLLCVP VQFFGGWYFY IQAYKALKHK TANMDVLIVL ATTIAFAYSL VILLVAVYER
AKVNPITFFD TPPMLFVFIA LGRWLEHIAK GKTSEALAKL ISLQATEATV VTLDSDNILL
SEEQVDVELV QRGDIIKVVP GGKFPVDGCV IEGHSMVDES LITGEAMPVA KKSGSTVITG
SINQNGSLLI RATHVGADTT LSQIVKLVEE AQTSKAPIQQ FADKLSGYFV PFIVIVSIAT
LLVWIIIGFL NFEVVDTYFP GYNRSISQTE TIIRFAFQAS ITVLCIACPC SLGLATPTAV
MVGTGVGAQN GILIKGGEPL EMAHKVKVVV FDKTGTITHG TPVVNQVKVL VESNRISRSK
ILAIVGTAES NSEHPLGAAV TKYCKQELDT ETLGTCIDFQ VVPGCGISCK VTNIEGFLHK
NNWKIEENNI KNAALFQTDG SNEPSSTSSS KIIDVQLSNA LNAQQYKVLI GNREWMIRNG
LIINNDVDDC MTEHERKGRT AVLVAVDDEL CGLIAIADTV KPEAELAVHI LKSMGLEVVL
MTGDNSKTAR CIASQVGITK VFAEVLPSHK VAKVKQLQEE GKRVAMVGDG INDSPALAMA
NVGIAIGTGT DVAIEAADVV LIRNDLLDVV ASFDLSRKTV KRIRINFVFA LIYNLVGIPI
AAGVFMPIGL VLQPWMGSAA MAASSVSVVL SSLFLKLYRK PAYENYELHT RSQIGQKSPS
EISVHVGIDD NSRISPQLSL LDRIVNYSRA SINSLLSDKR SLNSVVTNEP DKHSLLVGDF
REDDTAL
//
