ID A0A2Y9R8J9_TRIMA Unreviewed; 4499 AA.
AC A0A2Y9R8J9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=E3 ubiquitin-protein ligase UBR4 isoform X4 {ECO:0000313|RefSeq:XP_023587913.1};
GN Name=LOC101350055 {ECO:0000313|RefSeq:XP_023587913.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023587913.1};
RN [1] {ECO:0000313|RefSeq:XP_023587913.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the UBR4 family.
CC {ECO:0000256|ARBA:ARBA00009970}.
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DR RefSeq; XP_023587913.1; XM_023732145.1.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19680; UBR-box_UBR4; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR InterPro; IPR045841; E3_UBR4_N.
DR InterPro; IPR045189; UBR4-like.
DR InterPro; IPR047509; UBR4-like_UBR-box.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR Pfam; PF13764; E3_UbLigase_R4; 1.
DR Pfam; PF19423; E3_UBR4_N; 1.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 973..1046
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT ZN_FING 973..1046
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 1746..1785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2027..2080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2149..2283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2658..2702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1760..1785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2149..2207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2245..2265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2266..2283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2658..2681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2682..2701
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4499 AA; 499372 MW; 3EEC0A3584155E11 CRC64;
MATLASIIKE VDKDGLKGSS DEEFAAALYH FNHSLVTSDL QSPNLQNTLL QQLGVAPFSE
GPWPLYIHPQ SLSVLSRLLL IWQHKAGAQG DPDVPECLKV WDRFLSTMKQ NALQGVVPTE
MEDLNIEHLQ LLLLIFHNFT EKGQRAILTL FVQIIQELSV NMEAQMRSVP LILARLLLIF
DYLLHQYSKA PVYLFEQVQH NLLSPPFGWA SGSQDSSSRR VTIPLYHGFK EVEENWSKHF
SSDAVPQPRF YCVLSPEASE DDLNRLDSGA CDVLFSKLVK YDELYTALTS LLAAGSQLDT
VRRKENKNVT ALEACALQYY FLILWRILGI LPPSKAYMNQ LATNSPEMSE CDILHTLRWS
SRLRISSYVN WIKDHLIKQG MKAEHAGSLI ELASTKCSSV KYDVEIVEEY FARQISSFCG
IDCTTILQLH EIPSLQSIYT LDAAVSKVQV SLDEHFSKMA AETDPHKSSE ITKNLLPATL
QLIDTYASFT RAYLLQNFNE EGTSEKPSKE KLHGFAAVLA IGSSKCKANT LGTTLVQNLP
SSVQAVCESW NNINTNEFPN IGSWRNAFAN DTIPSESYIS AVQAAHLGTL CGQSLPLAAS
LKHTLLSLVR LTGDLIVWSD EMNPPQVIWT LLPLLLESST ESVAEISSNS LERILGPAES
DEFLARVYEK LITGCYNILA NHADPNSGLD ESILEECLQY LEKQLESSQA RKAMEEFFSE
SGELVQIMMA TANENLSAKF CNRVLKFFTK LFQLTEKSPN PSLLHLCGSL AQLACVEPVR
LQAWLTRMTT SPPKDSDQLD MIQENRQLLQ LLTTYIVREN SQVGEGVCAV LLGTLIPMAT
EMLANGDGTG FPELMVVMAT LASAGQGAGH LQLHNAAVDW LSRCKKYLSQ KNVVEKLNAN
VMHGKHVIIL ECTCHIMSYL ADVTNALSQS NGQGPSHLSV DGEERAIEVD SDWVEELAVE
EEDSQAEDSD EDSLCNKLCT FTITQKEFMN QHWYHCHTCK MVDGVGVCTV CAKVCHKDHE
ISYAKYGSFF CDCGAKEDGS CLALVKRTPS SGMSSTMKES AFQSEPRVSE SLVRHASTSP
ADKAKVTISD GKVADEEKPK KSSLCRTVEG CREELQNQAN FSFAPLVLDM LNFLMDAIQT
NFQQASAVGS SSRAQQALSE LHTVDKVVEM TDQLMVPTLG SQEGAFENVR MNYSGDQGQT
IRQLISAHVL RRVAMCVLSS PHGRRQHLAV SHEKGKITVL QLSALLKQAD SSKRKLTLTR
LASAPVPFTV LSLTGNPCKE DYLAVCGLKD CHVLTFSSSG SVSDHLVLHP QLATGNFIIK
AVWLPGSQTE LAIVTADFVK IYDLSIDALS PTFYFLLPSS KIRDVTFLFN EEGKNIIVIM
SSAGYIYTQL MEEASSAQQG PFYVTNVLEI NHEDLKDSNS QVAGGGVSVY YSHVLQMLFF
SYSQGKSFAA TISRTTLEVL QLFPINIKSS NGGSKTSPAL CQWSEVMNHP GLVCCVQQTT
GVPLVVMVKP DTFLIQEIKT LPAKAKIQDM VAIRHTACNE QQRTTMILLC EDGSLRIYMA
NVENTSYWLQ PSLQPSSVIS IMKPVRKRKT ATITTRASSQ VTFPIDFFEH NQQLTDVEFG
GNDLLQVYNA QQIKHRLNST GMYVANTKPG GFTIEISNNN STMVMTGMRI QIGTQAIERA
PSYIEIFGRT MQLNLSRSRW FDFPFTREEA LQADKKLNLF IGASVDPAGV TMIDAVKIYG
KTKEQFGWPD EPPEEFPSAS VSNICPSNLN QGNGTGDSDS AAPTTTSGTV LERLVVSSLE
ALESCFAVGP IIEKERNKNA AQELATLLLS LPAPASVQQQ SKSLLASLHT SRSAYHSHKD
QALLSKAVQC LNTSSKEGKD LDPEVFQRLV ITARSIAIMR PNNLVHFTES KLPQTETEGV
DEGKEPQKQL EGDCCSFITQ LVNHFWKLHA SKPKNAFLAP ACLPGLTHIE ATVNALVDII
HGYCTCELEC INTASKIYMQ MLLCPDPAVS FSCKQALIRV LRPRNKRRHV TLPSSPRSNT
PMGDKDDDDD DDADEKMQSS GIPNGGHIRQ ESQEQSEVDH GDFEMVSESM VLETAENVNN
GNPSPLEALL AGAEGFPPML DIPPDADDET MVELAIALSL QQDQQGSSSS ALGLQSLGLS
GQAPSSSSLD AGTLSDTTAS APASDDEGST AATDGSTLRT SPADHGGSVG SESGGSAVDS
VAGEHSVSGR SSAYGDATAE GHPAGPGSVS SSTGAISTTT GHQEGDGSEG EGEGEAEGDV
HTSNRLHMVR LMLLERLLQT LPQLRNVGGV RAIPYMQVIL MLTTDLDGED EKDKGALDNL
LSQLIAELGM DKKDVSKKNE RSALNEVHLV VMRLLSVFMS RTKSGSKSSI CESSSLISSA
TAAALLSSGA VDYCLHVLKS LLEYWKSQQN EEEPVATSQL LKPHTTSSPP DMSPFFLRQY
VKGHAADVFE AYTQLLTEMV LRLPYQIKKI ADTNSRIPPP VFDHSWFYFL SEYLMIQQTP
FVRRQVRKLL LFICGSKEKY RQLRDLHTLD SHVRGIKKLL EEQGIFLRAS VVTASSGSAL
QYDTLISLME HLKACAEIAA QRTINWQKFC IKDDSVLYFL LQVSFLVDEG VSPVLLQLLS
CALCGSKVLA AMAASTGSSS AASSSPPVAS SSGQATTQSK SSTKKSKKEE KEKEKEGESS
GSQEDQLCTA LVNQLNKFAD KETLIQFLRC FLLESNSSSV RWQAHCLTLH IYRNSSKSQQ
ELLLDLMWSI WPELPAYGRK AAQFVDLLGY FSLKTPQTEK KLKEYSQKAV EILRTQNHIL
TNHPNSNIYN TLSGLVEFDG YYLESDPCLV CNNPEVAFCY IKLSSIKVDT RYTTTQQVVK
LIGSHTISKV TVKIGDLKRT KMVRTINLYY NNRTVQAIVE LKNKPARWHK AKKVQLTPGQ
TEVKIDLPLP IVASNLMIEF ADFYENYQAS TETLQCPRCS ASVPANPGVC GNCGENVYQC
HKCRSINYDE KDPFLCNACG FCKYARFDFM LYAKPCCAVD PIENEEDRKK AVSNINTLLD
KADRVYHQLM GHRPQLENLL CKVNEAAPEK PQDDSGTAGG ISSTSASVNR YILQLAQEYC
GDCKNSFDEL SKIIQKVFAS RKELLEYDLQ QREAATKSSR TSVQPTFTAS QYRALSVLGC
GHTSSTKCYG CASAVTEHCI TLLRALATNP ALRHILVSQG LIRELFDYNL RRGAAAMREE
VRQLMCLLTR DNPEATQQMN DLIIGKVSTA LKGHWANPDL ASSLQYEMLL LTDSISKEDS
CWELRLRCAL SLFLMAVNIK TPVVVENITL MCLRILQKLI KPPAPTSKKN KDVPVEALTT
VKPYCNEIHA QAQLWLKRDP KASYEAWKKC LPIRGIDGNG KSPSKSELRH LYLTEKYVWR
WKQFLSRRGK RTSPLDLKLG HNNWLRQVLF TPATQAARQA ACTIVEALAT IPSRKQQVLD
LLTSYLDELS IAGECAAEYL ALYQKLITSA HWKVYLAARG VLPYVGNLIT KEIARLLALE
EATLSTDLQQ GYALKSLTGL LSSFVEVESI KRHFKSRLVG TVLNGYLCLR KLVVQRTKLI
DETQDMLLEM LEDMTTGTES ETKAFMAVCI ETAKRYNLDD YRTPVFIFER LCSIIYPEEN
EVTEFFVTLE KDPQQEDFLQ GRMPGNPYSS NEPGIGPLMR DIKNKICQDC DLVALLEDDS
GMELLVNNKI ISLDLPVAEV YKKVWCTTNE GEPMRIVYRM RGLLGDATEE FIESLDSTTD
EEEDEEEVYK MAGVMAQCGG LECMLNRLAG IKDFKQGRHL LTVLLKLFSY CVKVKVNRQQ
LVKLEMNTLN VMLGTLNLAL LAEQESKDSG GAAVAEQVLS IMEIILDESN AEPLSEDKSN
LLLTGDKDQL VMLLDQINST FVRSNPSVLQ GLLRIIPYLS FGEVEKMQIL VERFKPYCNF
DKYDEDHSGD DKVFLDCFCK IAAGIKNNSN GHQLKDLILQ KGITQNALDY MKKHIPSAKN
LDADIWKKFL SRPALPFILR LLRGLAMQHP ATQVLIGTDS ITNLHKLEQV SSDEGIGTLA
ENLLEALREH PDVNKKIDAA RRETRAEKKR MAMAMRQKAL GTLGMTTNEK GQVVTKTALL
KQMEELIEEP GLTCCICREG YKFQPTKVLG IYTFTKRVAL EEMENKPRKQ QGYSTVSHFN
IVHYDCHLAA VRLARGREEW ESAALQNANT KCNGLLPVWG PHVPESAFAT CLARHNTYLQ
ECTGQREPTY QLNIHDMKLL FLRFAMEQSF SADTGGGGRE SNIHLIPYII HTVLYVLNTT
RATSREEKNL QGFLEQPKEK WVESAFEVDG PHYFTVLALH ILPPEKWRPI RVEILQRLLV
TSQARAVAPG GATRLTDKTM KDYSAYRSSL LFWALVDLIY NMFKKVPTSN TEGGWSCSLA
EYIRHNDMPI SEAADKALKT FQEEFMPVET FSEFLDAAGL LSEINDPESF LKDLLNSIP
//
