ID   A0A2Y9RAR5_TRIMA        Unreviewed;       696 AA.
AC   A0A2Y9RAR5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Transducin-like enhancer protein 1 isoform X3 {ECO:0000313|RefSeq:XP_023591537.1};
GN   Name=LOC101359117 {ECO:0000313|RefSeq:XP_023591537.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023591537.1};
RN   [1] {ECO:0000313|RefSeq:XP_023591537.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC       {ECO:0000256|ARBA:ARBA00005969}.
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DR   RefSeq; XP_023591537.1; XM_023735769.1.
DR   AlphaFoldDB; A0A2Y9RAR5; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR005617; Groucho/TLE_N.
DR   InterPro; IPR009146; Groucho_enhance.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR   PANTHER; PTHR10814:SF29; TRANSDUCIN-LIKE ENHANCER PROTEIN 1; 1.
DR   Pfam; PF03920; TLE_N; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR01850; GROUCHOFAMLY.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   DOMAIN          18..125
FT                   /note="Groucho/TLE N-terminal Q-rich"
FT                   /evidence="ECO:0000259|Pfam:PF03920"
FT   REPEAT          496..537
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          538..579
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          130..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          26..53
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        134..176
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        237..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   696 AA;  75411 MW;  12AC9F1171425210 CRC64;
     MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH
     YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN
     AIIGSNSLLA PDNLRGADKR RNGPEFSNDI KKRKVDDKDS SHYDSDGDKS DDNLVVDVSN
     EDPSSPRASP AHSPRENGID KNRLLKKDAS SSPASTASSG SSTSLKSKEM SLHEKASTPV
     LKSSTPTPRS DMPTPGTSAT PGLRPGLGKP PAMDPLVNQA AAGLRTPLAV PGPYPAPFGM
     VPHAGMNGEL TSPGAAYASL HNMSPQMSAA AAAAAVVAYG RSPMVGFDPP PHMRVPTIPP
     NLAGIPGGKP AYSFHVTADG QMQPVPFPPD ALIGPGIPRH ARQINTLNHG EVVCAVTISN
     PTRHVYTGGK GCVKVWDISQ PGNKSPVSQL DCLNRDNYIR SCKLLPDGCT LIVGGEASTL
     SIWDLAAPTP RIKAELTSSA PACYALAISP DSKVCFSCCS DGNIAVWDLH NQTLVRQFQG
     HTDGASCIDI SNDGTKLWTG GLDNTVRSWD LREGRQLQQH DFTSQIFSLG YCPTGEWLAV
     GMESSNVEVL HVSKPDKYQL HLHESCVLSL KFAYCGKWFV STGKDNLLNA WRTPYGASIF
     QSKESSSVLS CDISVDDKYI VTGSGDKKAT VYEVIY
//