ID   A0A2Y9RCK1_TRIMA        Unreviewed;       250 AA.
AC   A0A2Y9RCK1;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Natural cytotoxicity triggering receptor 1 {ECO:0000256|ARBA:ARBA00040484};
DE   AltName: Full=Natural killer cell p46-related protein {ECO:0000256|ARBA:ARBA00041225};
GN   Name=LOC111821494 {ECO:0000313|RefSeq:XP_023592137.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023592137.1};
RN   [1] {ECO:0000313|RefSeq:XP_023592137.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
CC       {ECO:0000256|ARBA:ARBA00006531}.
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DR   RefSeq; XP_023592137.1; XM_023736369.1.
DR   AlphaFoldDB; A0A2Y9RCK1; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR   PANTHER; PTHR11738:SF14; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   Pfam; PF13927; Ig_3; 1.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000313|RefSeq:XP_023592137.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..250
FT                   /note="Natural cytotoxicity triggering receptor 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015888832"
FT   DOMAIN          34..118
FT                   /note="Immunoglobulin subtype"
FT                   /evidence="ECO:0000259|SMART:SM00409"
FT   DOMAIN          129..211
FT                   /note="Immunoglobulin subtype"
FT                   /evidence="ECO:0000259|SMART:SM00409"
FT   REGION          219..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   250 AA;  27775 MW;  77410CF468A9AA84 CRC64;
     MPSTLTALLC LGLCLSQMIS SQKYTLMKPI IWAKPNSIIP KGNPVTIWCK GIHEAIEYHL
     LFKGQLSALE RQKSHGLMNK VRFPIPAMTL HTAGRYNCIY LSGELWSKPS DPLDLVVTGM
     YDIPTLSVQP GPEVVSGENV TFHCHLETAT NTFFLLKEGR SSRPQQRYGK NQADFFMGPM
     TPAHRGTYRC FGSYNDFAWS LPSEPVKLLV TGSIGDTSFA PTEPNSYDGE DSWDVYPSTT
     KTGFQKGPTT
//