ID A0A2Y9REM6_TRIMA Unreviewed; 1401 AA.
AC A0A2Y9REM6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Latent-transforming growth factor beta-binding protein 1 isoform X9 {ECO:0000313|RefSeq:XP_023591911.1};
GN Name=LOC101345588 {ECO:0000313|RefSeq:XP_023591911.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023591911.1};
RN [1] {ECO:0000313|RefSeq:XP_023591911.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_023591911.1; XM_023736143.1.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 11.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF07645; EGF_CA; 14.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00179; EGF_CA; 14.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 5.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 201..233
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 359..400
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 428..465
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 479..531
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 717..758
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 840..880
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 881..921
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 922..962
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 963..1003
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1004..1045
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1046..1083
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1147..1201
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1324..1375
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT REGION 33..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 205..215
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 223..232
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1401 AA; 152262 MW; 9375326CED913EAA CRC64;
MCLRPQLCVC KPGTKGKACE TTATQDTLSI AVSGGQSPGA ASNWIPPEPA SKHTPSKKAD
TLPRISPVAQ MTLTLKPKPS VGLSQQIHSQ VTPLSSQNVM VHHGQTQEYV IKPKYFPAQK
VISGEQSAEG LLPLRYGQDP GTAPFQSSNH TGRIKVVFTP SICKVTCTKG SCQNSCEKGN
TTTLISENGH AADTLTATNF RVVICHLPCM NGGQCSSRDK CQCPPNFTGK LCQIPVHGAN
VPKLYQHSQQ SGKALGTHVV HSTHTLPLTM TNQQGVKVKF PPNIVNIHVK HPPEASVQIH
QVSRIDDPTG QKVKETQPGQ SQVSYQGLPI QKTQTVHSTY SHQQVIPHIY PVAAKTQLGR
CFQETIGSQC GKPLPGLSKQ EDCCGTVGTS WGFNKCQKCP KKPAYHGYNQ MMECLQGYKR
VNNTFCQDIN ECQLQGVCPN GECLNTMGSY RCTCKMGFGP DPTFSSCIPD TPMISEEKGP
CYRLVSSGRQ CMHPLSVHLT KQLCCCSVGK AWGPHCEKCP LPGTAAFKEI CPGGMGYTVS
GVHRRRPIHH HVGKGPVFVK PKNAQPVAKS THPPPLPAKE EPVEALTFSQ EHGPGVAEPE
VATAPPEKEI PSLDQEKTKL EPGQLQLSPG VSTVHLHPQF PVVIEETSPP VPVEVAPEAS
TSSARQVIAP TQVTEINECT VNPDICGAGH CINLPVRYTC ICYEGYKFIE QQRKCVDIDE
CTQVQQLCSQ GHCENTEGSF LCICPAGFMA SEEGSNCLDV DECLRPDVCG EGHCVNTMGT
FQCEYCDSGY RMTRTGNCED INECLTPSTC PDEQCVNSPG SYQCIPCTEG FRGWNGQCLD
VDECLEPNVC VNGTCFNLEG SYMCSCHQGY SPTLDRKHCK DIDECQQGNL CISGQCKNTE
GSFRCTCGQG YQLSAAKDQC EDIDECQHHR LCTNGQCRNM EGSFQCVCDQ GYRASALGDH
CEDINECLEN NHICLGGDCV NTAGSYDCTC PNGFQLNDSK RCQDINECEQ PGLCGPHGEC
LNTDGSFQCV CEQGFSISAD GPTCEDIDEC VNNTVCDSHG FCDNTAGSFR CLCYQGFQAP
QDGQGCVDVN ECELLSGVCG EAFCENVEGS FLCVCADENQ EYSPMTGQCR SQASEDLDVD
QPKEEKKECY YNLNDASLCD NVLAPNVTKQ ECCCTSGAGW GDNCEIFPCP VSGTAEFTEM
CPRGKGFVPT GESTHGVGGQ NYKDADECSL FGQEICKNGF CLNTQPGYEC YCKQGTYYDP
VKLQCFDIDE CQDPSSCIDG QCINTEGSYN CFCTHPMVLD ASEKRCIQPA ESNEQIEETD
VYQDLCWEHL SDEYVCSRPL VGKQTTYTEC CCLYGEAWGM QCALCPMKDS GAQHCLGEQS
VTDGNSAGEI QGINCTTCHR L
//
