ID   A0A2Y9RES9_TRIMA        Unreviewed;       426 AA.
AC   A0A2Y9RES9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Zinc transporter ZIP8 {ECO:0000313|RefSeq:XP_023590474.1};
GN   Name=LOC101351603 {ECO:0000313|RefSeq:XP_023590474.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023590474.1};
RN   [1] {ECO:0000313|RefSeq:XP_023590474.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000256|ARBA:ARBA00006939}.
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DR   RefSeq; XP_023590474.1; XM_023734706.1.
DR   AlphaFoldDB; A0A2Y9RES9; -.
DR   STRING; 127582.A0A2Y9RES9; -.
DR   KEGG; tmu:101351603; -.
DR   InParanoid; A0A2Y9RES9; -.
DR   OrthoDB; 5488029at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR003689; ZIP.
DR   PANTHER; PTHR12191:SF2; METAL CATION SYMPORTER ZIP8; 1.
DR   PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR   Pfam; PF02535; Zip; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..426
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016143820"
FT   TRANSMEM        128..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        278..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        332..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        359..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        398..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   426 AA;  46143 MW;  D936A327A0D82263 CRC64;
     MAPGQAVAGL LLLAAAGLGE AAAGHGLAFS EDVLSVFGAN RSLSVPQLGR LLELLGSAPV
     KGAPELGQLH FNQCLSAEEI FFLHGFSNAT QITSSNFSTI CPAVLQQLSF HPCEAKSKHH
     TKPSLSEVWG YGFLSVTIIN LASLLGLVLT PMIKKPYFPK ILTYFVGLAI GTLFSNAIFQ
     LIPESFLPTI SFLFPVMNHK GLPPTVKDFM VTTIFLSRHN PSPNFLYPLD FQEIGNHVDW
     FSAILQDEKS EPSSCTCLKG PKLSEIGTIA WMITLSDALH NFIDGLAIGA SFTLSLLQGL
     STSIAILCEE FPHELGDFVI LLNAGMSTRQ ALLFNFLSAC SCYVGLAFGI LVGNNFSPYI
     IFALAGGMFL YISLADMFPE MNDMLREKVT GRKTDFTFFM IQNAGMLTGF VAILLITLFA
     GDIELE
//