ID A0A2Y9RGC9_TRIMA Unreviewed; 267 AA.
AC A0A2Y9RGC9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=sn-1-specific diacylglycerol lipase ABHD11 {ECO:0000256|ARBA:ARBA00044064};
DE EC=3.1.1.116 {ECO:0000256|ARBA:ARBA00026104};
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 11 {ECO:0000256|ARBA:ARBA00042703};
GN Name=LOC101361878 {ECO:0000313|RefSeq:XP_023591019.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023591019.1};
RN [1] {ECO:0000313|RefSeq:XP_023591019.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-didecanoylglycerol + H2O = decanoate + decanoylglycerol +
CC H(+); Xref=Rhea:RHEA:48596, ChEBI:CHEBI:11152, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:90605;
CC Evidence={ECO:0000256|ARBA:ARBA00043771};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-
CC glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol +
CC H(+) + octadecanoate; Xref=Rhea:RHEA:77107, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:77129,
CC ChEBI:CHEBI:186738; Evidence={ECO:0000256|ARBA:ARBA00043706};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
CC + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) +
CC octadecanoate; Xref=Rhea:RHEA:38507, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:52392,
CC ChEBI:CHEBI:75728; Evidence={ECO:0000256|ARBA:ARBA00043768};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-
CC octadecenoyl)-glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:77103,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629,
CC ChEBI:CHEBI:73990, ChEBI:CHEBI:75468;
CC Evidence={ECO:0000256|ARBA:ARBA00043740};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty
CC acid + H(+); Xref=Rhea:RHEA:33275, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17389, ChEBI:CHEBI:17815,
CC ChEBI:CHEBI:28868; EC=3.1.1.116;
CC Evidence={ECO:0000256|ARBA:ARBA00043667};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a
CC fatty acid + H(+); Xref=Rhea:RHEA:38503, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:64683,
CC ChEBI:CHEBI:77272; Evidence={ECO:0000256|ARBA:ARBA00043742};
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily.
CC {ECO:0000256|ARBA:ARBA00008645}.
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DR RefSeq; XP_023591019.1; XM_023735251.1.
DR AlphaFoldDB; A0A2Y9RGC9; -.
DR ESTHER; trima-a0a2y9dtj5; ABHD11-Acetyl_transferase.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR PANTHER; PTHR46118; PROTEIN ABHD11; 1.
DR PANTHER; PTHR46118:SF4; PROTEIN ABHD11; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT DOMAIN 58..165
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT REGION 13..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 267 AA; 29075 MW; 1E0A3FD43ACE887E CRC64;
MLRWARAWRL PHGGRGASRP SFPRVPVANS SSSGGGGGVE LRPLPLSFTL LDGEAGRPAL
VFLHGVCGCK NNFNSVAKAL ARRTGRKVLT VDARNHGDSP HSPDMSYEAM SRDLQDLLPQ
LGLVPCILVG HSMGGKTAML LALQRPDLVE RLIAVDSSPA ETTFLSNLPS YVAAMRAVEI
PDEVPRSHAR KLADEQLSPV VQDVVTRQFL LTNLVEVDGR FVWRVNLDAV AQHLQELLAF
PPRQESYLGP TLFLLGGNSQ FVQCRLC
//
