ID   A0A2Y9RH45_TRIMA        Unreviewed;      1185 AA.
AC   A0A2Y9RH45;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Protocadherin-12 {ECO:0000313|RefSeq:XP_023591279.1};
GN   Name=LOC101349035 {ECO:0000313|RefSeq:XP_023591279.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023591279.1};
RN   [1] {ECO:0000313|RefSeq:XP_023591279.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_023591279.1; XM_023735511.1.
DR   AlphaFoldDB; A0A2Y9RH45; -.
DR   KEGG; tmu:101349035; -.
DR   InParanoid; A0A2Y9RH45; -.
DR   OrthoDB; 4259465at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 6.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF42; PROTOCADHERIN-12; 1.
DR   Pfam; PF00028; Cadherin; 4.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 3.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..1185
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016143239"
FT   TRANSMEM        716..740
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          28..135
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          136..244
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          245..352
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          355..460
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          461..565
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          618..717
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   REGION          785..808
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          855..927
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          973..1005
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1154..1185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        789..803
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1185 AA;  128844 MW;  35D2DF60442E0FFD CRC64;
     MMQLLQFLLG LWGPGGYLFL SGDCQEVATL TVKYQVLEEV PSGTVIGKLS RELGREERRQ
     PEGAVFQVLQ LPQVLPIQVD AEDGLLSTGR RLDREQLCRQ QDPCLVSFDV LATGDFALIH
     VEIQVLDIND HQPQFPKGEQ ELEISESASL HTRIPLDRAV DPDTGPNTLH TYTLSPSEHF
     ALDVIVGPDE TKYAELVVVK ELDREIHSFF DLVLTAYDSG DPPKSGTSLV KVNVLDSNDN
     SPVFAESSLA LEIQEDAALG TLLINLTATD PDQGPNGEVE FFLSKHAPPE VLDTFSIDAK
     TGQFILRQPL DYEKNPAYEV DVQARDLGPN PIPAHCKVLI KVLDVNDNAP SIHVTWASQS
     PLVSEAVPKD SFIALVMAND LDSGNNGLVH CWLSQELGHF RLKRTNGNTY MLLTNATLDR
     EQWPEYTLTL LAQDQGLQPL SAKKQLSIQI TDANDNAPVF EKSRYEISTR ENNLPSLHLI
     TVKAHDADLG INGKISYRIQ DSPVSHLVAI DSDTGEVTAQ RTLDYEQMAS FEFRVIAEDR
     GQPQLASSVS MWVSLLDAND NSPEVVQPVL NNGKASLSVL VNASTGHLLV PIETFNGLGP
     ADVDIPPLAT HSSPPFLLTT IVARDADSGA NGELLYSIRR GNKACLFVLS PHLGQLFINV
     TNASSLIGSE WELEIVVEDR GSPSLQTQAL LKVMFVTSVD HLRDLAHEPG ALSTPVLTVI
     CLVVLLAIFG LILALVMSIC RTEKKDNRAY NCREAESTYR HQPKRPQKHI QKADIHLVPV
     LRGQVDEPGE VGQPHKDTGK EANTSEGWDP CLQAPFHLTP TLYRTLRNQG NLGALTESQE
     VLQDTVNLLF NHPRQRNASR ENLNFPEPQP ALGQPRSKPL KAAGSPTGRL LGDQGIGEAP
     LSPPASSATL RRKRNLNGKM VPEKESGPRQ ILRSLVRLSV AAFAERNPVE ELTMDSPPVQ
     QISQLLSLLH QGQFQPKPNH RGNKYSAKPG SGGRSTVLDT EGTGARVGGQ AELDQEEGLL
     DPEEDLSVKQ LLEEELSSLL DPHTGLALDR LSAPDPAWMA RLSLPLTTNY RDNVCSPDAA
     AAEEPRTFQT FGKAAGPELS PTGTRLASTF VSEMSSLLEM LLAQSSSVVP VEAASEVLRR
     LSVCGRTLSL DLATSGTSGT EAQGAPGGKT GAKGRTCSSS SSRGL
//