ID A0A2Y9RI49_TRIMA Unreviewed; 774 AA.
AC A0A2Y9RI49;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Adhesion G-protein coupled receptor G4 {ECO:0000313|RefSeq:XP_023591268.1};
GN Name=LOC101340470 {ECO:0000313|RefSeq:XP_023591268.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023591268.1};
RN [1] {ECO:0000313|RefSeq:XP_023591268.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_023591268.1; XM_023735500.1.
DR AlphaFoldDB; A0A2Y9RI49; -.
DR STRING; 127582.A0A2Y9RI49; -.
DR KEGG; tmu:101340470; -.
DR InParanoid; A0A2Y9RI49; -.
DR OrthoDB; 4893596at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15997; 7tmB2_GPR112; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF277; ADHESION G-PROTEIN COUPLED RECEPTOR G4; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_023591268.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 395..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 396..643
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 774 AA; 87410 MW; 02E206EA9C0A4072 CRC64;
MNRRASVYHV TCLRKKWTKL LEKGKEWLQF PVYHTEPGKC KAVETASKFK GTYKWLLTNP
TETAQTRCIK NEDGKATRIC SISINTGKSQ WEKPKFKQCR LLQGLPNKIV DLANITINDE
NAHDVAEHIL NLINESPPLD EEETKIIVSK VADISQCDEI SMNLTQIVLQ IINAVLGKQN
NSASDLHEVS NEILRIIDRA GHKMEFSGRT ANLTVAKLAL AVLQVDHKFE GMAFSIRSFE
EGIDPEIYLS EDPLGKILAS IYLPKSLRER LHLNNLQTIL FNFFGQTSLF KIKNFTKALT
TYVVSASISD TSIQNLADPV VITLHHIEGS PNYGQVHCAF WDFGKNNGLG GWNSSGCKVN
ETNVNYTICQ CDHLTHFGVL MDLSRSTVDT VNERILVLIT YAGCGISSIF LGIAIVTYIV
FHKLRKDYPS KILINLCTAL LMLNMMFLVN SWSASFQKVG LCITAAVALH YFLLVSLTWM
GLEAVHMYFA LVKVFNIYIP NYILKFCLVG WGIPAVMVAI ILSVKKDLYG TLSSGTPFCW
IKDDSIFYIS VVAYFCLIFI TNLFMFCAVI VQLNSVKAHS QKTRRKMILH DLKGITSLTF
LLGLTWGFAF FAWGPVRILF LYLFAIFNTL QGFLIFVFHC AMKENVREQW QIHLCCKWFR
LDNSSDVSSR CGLNVGYKQE KSRKTFEHKL LTPSLKSTTT NSTFKSLGCT QGTPSEISFP
SDGFDEDPLS CEVVANCGRS ILPVEIKMNS IHEQRFLQYF PAEIPSPLPD WGKF
//
