ID A0A2Y9RK47_TRIMA Unreviewed; 1340 AA.
AC A0A2Y9RK47;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Latent-transforming growth factor beta-binding protein 1 isoform X14 {ECO:0000313|RefSeq:XP_023591923.1};
GN Name=LOC101345588 {ECO:0000313|RefSeq:XP_023591923.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023591923.1};
RN [1] {ECO:0000313|RefSeq:XP_023591923.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_023591923.1; XM_023736155.1.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 12.
DR Gene3D; 2.10.25.10; Laminin; 17.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF07645; EGF_CA; 15.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00179; EGF_CA; 16.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 11.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 11.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1340
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015976090"
FT DOMAIN 73..105
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 231..272
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 300..337
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 351..397
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 536..577
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 659..699
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 700..740
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 741..781
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 782..822
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 823..864
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 865..902
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 966..1020
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1143..1196
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1240..1276
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1281..1325
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 407..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 77..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 95..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1340 AA; 147064 MW; 67380DF0E9D663FF CRC64;
MDTKLMCLLF FFSLPPLLAS NHTGRIKVVF TPSICKVTCT KGSCQNSCEK GNTTTLISEN
GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNFT GKLCQIPVHG ANVPKLYQHS
QQSGKALGTH VVHSTHTLPL TMTNQQGVKV KFPPNIVNIH VKHPPEASVQ IHQVSRIDDP
TGQKVKETQP GQSQVSYQGL PIQKTQTVHS TYSHQQVIPH IYPVAAKTQL GRCFQETIGS
QCGKPLPGLS KQEDCCGTVG TSWGFNKCQK CPKKPAYHGY NQMMECLQGY KRVNNTFCQD
INECQLQGVC PNGECLNTMG SYRCTCKMGF GPDPTFSSCI PDTPMISEEK GPCYRLVSSG
RQCMHPLSVH LTKQLCCCSV GKAWGPHCEK CPLPGTAKEE PVEALTFSQE HGPGVAEPEV
ATAPPEKEIP SLDQEKTKLE PGQLQLSPGV STVHLHPQFP VVIEETSPPV PVEVAPEAST
SSARQVIAPT QVTEINECTV NPDICGAGHC INLPVRYTCI CYEGYKFIEQ QRKCVDIDEC
TQVQQLCSQG HCENTEGSFL CICPAGFMAS EEGSNCLDVD ECLRPDVCGE GHCVNTMGTF
QCEYCDSGYR MTRTGNCEDI NECLTPSTCP DEQCVNSPGS YQCIPCTEGF RGWNGQCLDV
DECLEPNVCV NGTCFNLEGS YMCSCHQGYS PTLDRKHCKD IDECQQGNLC ISGQCKNTEG
SFRCTCGQGY QLSAAKDQCE DIDECQHHRL CTNGQCRNME GSFQCVCDQG YRASALGDHC
EDINECLENN HICLGGDCVN TAGSYDCTCP NGFQLNDSKR CQDINECEQP GLCGPHGECL
NTDGSFQCVC EQGFSISADG PTCEDIDECV NNTVCDSHGF CDNTAGSFRC LCYQGFQAPQ
DGQGCVDVNE CELLSGVCGE AFCENVEGSF LCVCADENQE YSPMTGQCRS QASEDLDVDQ
PKEEKKECYY NLNDASLCDN VLAPNVTKQE CCCTSGAGWG DNCEIFPCPV SGTAEFTEMC
PRGKGFVPTG ESTHGVGGQN YKDADECSLF GQEICKNGFC LNTQPGYECY CKQGTYYDPV
KLQCFDIDEC QDPSSCIDGQ CINTEGSYNC FCTHPMVLDA SEKRCIQPAE SNEQIEETDV
YQDLCWEHLS DEYVCSRPLV GKQTTYTECC CLYGEAWGMQ CALCPMKDSD DYAQLCNIPV
TGHRQPYGRD ALVDFSEQYA PEANPYFIQD RFLNSFEELQ AEECGILNGC ENGRCVRVQE
GYTCDCFDGY HLDMAQMTCV DVNECDELNN RMSLCKNAKC INTEGSYKCL CLPGYVPSDK
PNYCTPLNTA MNLEKDSDLE
//
