ID A0A2Y9RKW0_TRIMA Unreviewed; 1000 AA.
AC A0A2Y9RKW0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Insulin-degrading enzyme isoform X2 {ECO:0000313|RefSeq:XP_023595795.1};
GN Name=LOC101340940 {ECO:0000313|RefSeq:XP_023595795.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023595795.1};
RN [1] {ECO:0000313|RefSeq:XP_023595795.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_023595795.1; XM_023740027.1.
DR AlphaFoldDB; A0A2Y9RKW0; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 55..193
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 219..397
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 403..683
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 687..870
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 1000 AA; 115728 MW; CD2468D428071646 CRC64;
MGRWSPEKCC HYLGFQKKTY SKMNNPAIKR IGNHITKSPE DKREYRGVEL ANGIKVLLIS
DPTTDKSSAA LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN
AFTSGEHTNY YFDVSHEHLE GALDRFAQFF LCPLFDASCK DREVNAVDSE HEKNVMNDAW
RLFQLEKATG NPKHPFSKFG TGNKYTLETR PNQEGIDVRQ ELLKFHSTYY SSNLMAICVL
GRESLDDLTN LVVKLFSEVE NKNVPLPEFP EHPFQQEHLK QLYKIVPIKD IRNLYVTFPI
PDLQKYYKSN PGHYLGHLIG HEGPGSLLSE LKSKGWVNTL VGGQKEGARG FMFFIINVDL
TEEGLLHVED IILHMFQYVQ KLRAEGPQEW VFQECKDLNA VGFRFKDKER PRGYTSKIAG
ILHYYPLEEV LTAEYLLEEF RPDLIEMVLD KLRPENVRVA VVSKSFEGKT DRTEEWYGTQ
YKQEAIPDEV IEKWQNADLN GKFKLPTKNE FIPTNFEILS LEKEATPYPA LIKDTAMSKL
WFKQDDKFFL PKACLNFEFF SPFAYVDPLH CNMAYLYLEL LKDSLNEYAY AAELAGLSYD
LQNTIYGMYL SVKGYNDKQP ILLKKIIEKM ATFEIDEKRF EIIKEAYMRS LNNFRAEQPH
QHAMYYLRLL MTEVAWTKEE LKEALDDVTL PRLKAFIPQL LSRLHIEALL HGNIAKQAAL
GIMQMVEDTL IEHAHTKPLL PSQLVRYREV QLPDRGWFVY QQRNEIHNNC GIEIYYQTDM
QSTSENMFLE LFCQIISEPC FNTLRTKEQL GYIVFSGPRR ANGIQGLRFI IQSEKPPHYL
ESRVEAFLVT MEKSIEDMTE EAFQKHIQAL AIRRLDKPKK LAAECAKYWG EIISQQYNFD
RDNIEVAYLK TLTKEDIIKF YQEMLAVDAP RRHKVSVHVL AREMDSCPAV GEFPCQNDVN
LPQAPALPQP EVIQNMTEFK RGLPLFPLVK PHINFMAAKL
//