ID A0A2Y9RKW2_TRIMA Unreviewed; 447 AA.
AC A0A2Y9RKW2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Transcription factor {ECO:0000256|PIRNR:PIRNR009404};
GN Name=LOC101342617 {ECO:0000313|RefSeq:XP_023595102.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023595102.1};
RN [1] {ECO:0000313|RefSeq:XP_023595102.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR009404,
CC ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|PIRNR:PIRNR009404,
CC ECO:0000256|RuleBase:RU003796}.
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DR RefSeq; XP_023595102.1; XM_023739334.1.
DR AlphaFoldDB; A0A2Y9RKW2; -.
DR STRING; 127582.A0A2Y9RKW2; -.
DR InParanoid; A0A2Y9RKW2; -.
DR OrthoDB; 1343784at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd14458; DP_DD; 1.
DR Gene3D; 1.20.140.80; Transcription factor DP; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR038168; TF_DP_C_sf.
DR InterPro; IPR014889; Transc_factor_DP_C.
DR InterPro; IPR015648; Transcrpt_fac_DP.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12548; TRANSCRIPTION FACTOR DP; 1.
DR PANTHER; PTHR12548:SF5; TRANSCRIPTION FACTOR DP-2; 1.
DR Pfam; PF08781; DP; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR PIRSF; PIRSF009404; Transcription_factor_DP; 1.
DR SMART; SM01138; DP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PIRNR:PIRNR009404, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|PIRNR:PIRNR009404, ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transcription {ECO:0000256|PIRNR:PIRNR009404,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR009404,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 127..209
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 216..360
FT /note="Transcription factor DP C-terminal"
FT /evidence="ECO:0000259|SMART:SM01138"
FT REGION 410..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..447
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 49308 MW; B584781C7B556469 CRC64;
MTAKHVGLTS TNAELRGFID QNLSPTEGNI SFVAFPAPNT NSPTKILPKT LGPINVNVGP
QMIISTPQRL TSSGSVLIGS PYTPAPAMVT QTHIAEATGW VPGDRKRARE FIDSDFSESK
RSKKGDKNGK GLRHFSMKVC EKVQRKGTTS YNEVADELVS EFTNSNNHLA AESQAYDQKN
IRRRVYDALN VLMAMNIISK EKKEIKWIGL PTNSAQECQN LEIEKQRRIE RIKQKRAQLQ
ELLLQQIAFK NLVQRNRQNE QQNQGPPALN STIQLPFIII NTSRKTVIDC SISSDKFEYL
FNFDNTFEIH DDIEVLKRMG MSFGLESGAC SLEDLKLAKS LVPKALEGYI TDISTGPSWL
NQGLLLNPTQ SVSNLDLTTG ATVTQSSVNQ GLCLDAEVAL ATGQLLAPNS HQSSSAASHC
SESRGETPCS FNDEDEDDEE EDSSSPE
//
