ID A0A2Y9RLE7_TRIMA Unreviewed; 1879 AA.
AC A0A2Y9RLE7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Ankyrin-2 isoform X12 {ECO:0000313|RefSeq:XP_023595970.1};
GN Name=LOC101354866 {ECO:0000313|RefSeq:XP_023595970.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023595970.1};
RN [1] {ECO:0000313|RefSeq:XP_023595970.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_023595970.1; XM_023740202.1.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 22.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 19.
DR PROSITE; PS50088; ANK_REPEAT; 19.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 63..95
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 96..128
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 129..161
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 232..264
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 265..297
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 298..330
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 331..363
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 364..396
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 397..429
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 430..462
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 463..495
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 496..528
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 529..561
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 562..594
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 595..627
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 628..660
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 661..693
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 694..726
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 727..759
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 947..1102
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1104..1250
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1430..1514
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1551..1572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1638..1752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1773..1795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1850..1879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1638..1661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1668..1684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1715..1752
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1850..1871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1879 AA; 206914 MW; 9A058BD3C2CBA9CC CRC64;
MMNEDAGQKS DSGEKFNGSS QRKKRPKKSD SNASFLRAAR AGNLDKVVEY LKGGIDINTC
NQNGLNALHL AAKEGHVGLV QELLGRGSAV DSATKKGNTA LHIASLAGQA EVVKVLVKEG
ANINAQSQNG FTPLYMAAQE NHIDVVKYLL ENGANQSTAT EDGFTPLAVA LQQGHNQAVA
ILLENDTKGK VRLPALHIAA RKDDTKSAAL LLQNDHNADV QSKMMANRTT ESGFTPLHIA
AHYGNVNVAT LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL
TPLHCAARSG HDQVVELLLE RGAPLLARTK NGLSPLHMAA QGDHVECVKH LLQHKAPVDD
VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT PLHIACKKNR IKVMELLVKY
GASIQAITES GLTPIHVAAF MGHLNIVLLL LQNGASPDVT NIRGETALHM AARAGQVEVV
RCLLRNGALV DARAREEQTP LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE
GQVDVASVLL EAGAAHSLAT KKGFTPLHVA AKYGSLDVAK LLLQRRAAAD SAGKNGYTPL
HIAAKKNQMQ IASTLLNYGA ETNIVTKQGV TPLHLASQEG HTDMVTLLLD KGANIHTATK
SGLTSLHLAA QEDKVNVADI LTKHGADQDA HTKLGYTPLI VACHYGNVKM VNFLLKQGAN
VNAKTKNGYT PLHQAAQQGH THIINVLLQH GAKPNATTAN GNTALAIAKR LGYISVVDTL
KVVTEEVTTT TTTITEKHKL NVPETMTEVL DVSDEEGDDT MTGDGGEYLR PEDLKELGDD
SLPSSQFLDG MNYLRYSLEG GRSDSLRSFS SDRSHTLSHA SYLRDSAMID DTVVIPSHQV
STLAKEAERN SYRLSWGTEN LDNVALSSSP IHSGHASPCL DRDNSSFLVS FMVDARGGAM
RGCRHNGLRI IIPPRKCTAP TRVTCRLVKR HRLATMPPMV EGEGLASRLI EVGPSGAQFL
GPVIVEIPHF AALRGKEREL VVLRSENGDS WKEHYCEYTE DELNEILNGM DEVLDSPEDL
EKKRICRIIT RDFPQYFAVV SRIKQDSNLI GPEGGVLSST VVPQVQAVFP EGALTKRIRV
GLQAQPMHSE LVKKILGNKA TFSPIVTLEP RRRKFHKPIT MTIPVPKAAS DVMLNGFGGD
APTLRLLCSI TGGTTPAQWE DITGTTPLTF VNECVSFTTN VSARFWLIDC RQIQESVTFA
SQVYREIICV PYMAKFVVFA KSHDPIEARL RCFCMTDDKV DKTLEQQENF AEVARSRDVE
VLEGKPIYVD CFGNLVPLTK SGQHHIFSFF AFKENRLPLF VKVRDTTQEP CGRLSFMKEP
KSTRGLVHQA ICNLNITLPV YTKESESDQE QEEEIDMTSE KNPQDEQERI EERLAYIADH
LGFSWTELAR ELDFTEEQIH QIRIENPNSL QDQSHALLKY WLERDGKHAT DTGLIECLTK
INRMDIVHLM EASTEPFQER ISHSYAEIEQ TITLDHSEGF SVLQEELCTA QHKQKEEQPE
SKESETCDCP PIVSEEDISV GYSMFQDYIP KTEGDTSAAE LLSQTDKEQV QQDFSGKMQD
LTEESSLEHQ QEYFVTTPGT EVSETLKSPV VSGSPSKIPE EISTPSEEER PYLQTPTSSE
WGGSPIVQEP EESPVQREES SPRRTSLVIV ESADDQPRIF ERPDEDVAFQ KGDDMPDIPP
ETVTEEKYTD EHGHTVVKKV TRKIIRRYVS SDGTEKEEIT MQGMPQEPVN IEEGDDYSKV
IKRVVLKSDT EQSEVTLSEP SILSGTSQFQ AEPVEGRRVS KVVKTTMVRG ERMEKHLGDS
SLARDLPSAK DDFEEDNDE
//
