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Database: UniProt
Entry: A0A2Y9RPQ1_TRIMA
LinkDB: A0A2Y9RPQ1_TRIMA
Original site: A0A2Y9RPQ1_TRIMA 
ID   A0A2Y9RPQ1_TRIMA        Unreviewed;       583 AA.
AC   A0A2Y9RPQ1;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
GN   Name=LOC101354366 {ECO:0000313|RefSeq:XP_023595661.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023595661.1};
RN   [1] {ECO:0000313|RefSeq:XP_023595661.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC       {ECO:0000256|RuleBase:RU365065}.
CC   -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU365065}.
CC   -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC       subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC       ECO:0000256|RuleBase:RU365065}.
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DR   RefSeq; XP_023595661.1; XM_023739893.1.
DR   AlphaFoldDB; A0A2Y9RPQ1; -.
DR   STRING; 127582.A0A2Y9RPQ1; -.
DR   InParanoid; A0A2Y9RPQ1; -.
DR   OrthoDB; 38357at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   CDD; cd17480; MFS_SLC40A1_like; 1.
DR   InterPro; IPR009716; Ferroportin-1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR   PANTHER; PTHR11660:SF47; SOLUTE CARRIER FAMILY 40 MEMBER 1; 1.
DR   Pfam; PF06963; FPN1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|RuleBase:RU365065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT   TRANSMEM        26..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        65..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        134..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        314..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        346..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        381..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        462..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        502..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        531..551
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
SQ   SEQUENCE   583 AA;  63817 MW;  F95E35DE0069A1AF CRC64;
     MTRARDQNRR GGCCGSLANY LTSAKFLLYV SHSLSTWPLV FLFKGDRMWH FAVSVFLVEL
     YGNSLLLTAV YGLVVAGSVL VLGAIIGDWV DKNPRLKVAQ TSLVVQNVSV TLCGIILMMV
     FLHKNELLTM YHGWVLTSCY ILIITIANIA NLASTATTIT IQRDWIVVVA GEDRSKLADM
     NATIRRIDQL TNILAPMAVG QIMTFGSPVI GCGFISAWNL MSMCVEYFLL WKVYQKTPAL
     AVKAAFKVEE AELKQLNVHK DTEPKPLEGT RLMGDKDPDI LELEHKQEPS CASQIAEPFR
     TFRDGWVSYY NQPIFLAGLG LAFLYMTVLG FDCITTGYAY TQGLSGSILS ILMGASAITG
     ITGTVAFTCL RRKCGLVRTG LISGFAQLSC LILCVISVFM PGSPLDLSVS PFEDIRSRFI
     QIEPLPTTTT TKIPGTFSTT EMHVSNGSSP ANIAIETSPK SVPIISVSLL FAGVIAARIG
     LWSFDLTVTQ LLQENVIESE RGIINGVQNS MNYLLDLLHF IMVILAPNPE AFGLLVLISV
     SFVAMGHTMY FRFAQKTLGS RLFACGPDGK EVTNENQTNT SVV
//
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