ID A0A2Y9RPU7_TRIMA Unreviewed; 1043 AA.
AC A0A2Y9RPU7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=LOC101347636 {ECO:0000313|RefSeq:XP_023593588.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023593588.1};
RN [1] {ECO:0000313|RefSeq:XP_023593588.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR RefSeq; XP_023593588.1; XM_023737820.1.
DR AlphaFoldDB; A0A2Y9RPU7; -.
DR STRING; 127582.A0A2Y9RPU7; -.
DR InParanoid; A0A2Y9RPU7; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF16; ANOCTAMIN-3; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 457..484
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 534..552
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 609..633
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 653..676
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 704..726
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 821..843
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 871..895
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 968..987
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 219..443
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 446..1011
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 121281 MW; 60D4A59B5BDF6B79 CRC64;
MSAAMFELDN LSPGSSRQEH VSNSDFTLTC LTELSSDSSQ LELQHSNSVP DGLQKLCLSH
HGLEKSAWAA EGKYQQGMNI SKSEMVKETS LKPSRRSLPC LAQSYTYSQS LSQSTSLFQS
NESESQAPTS VTTVSIDKAA QVNAEENKKD SVLNCSFTDL SDFCLALEKD KDYTDESEHA
NYDRSRLIRD SVCKDKPEPK PKSLPKNDMN YIASSGLLFK DGKKRIDYIL VYRKSNIQYD
RRNTFEKNLR AEGLMLEKEP AVANTDIMFI KIHIPWDTLC KYAERLNIRM PFRKKCYFTD
RRSKSMGRMK KNLKKIMKWM PQNPMALDKS AFPDLEELEC YTGPFSRARI HHFIINNKDT
FFSNATRSRI VYHMLQRTKY ENGISKVGIC KLINNGAYEA AFPPHEGAYK SRQPIKTHGP
QNNRHLLYER WARWGMWYKH QPLDLIRRYF GEKIGLYFAW LGWYTGMLIP AAIVGLCVFF
YGLFTMNGSQ VSQEICAAAE VFMCPLCDKN CSLQRLNDSC IYAKVTYLFD NGGTVFFAIF
MAIWATVFLE FWKRRRSILT YAWDLIEWEE EEETLRPQFE AKYYTMERVN PITGKPEPHQ
PFSDKITRLL VSVSGIFFMI SLVITAVFAV VVYRLVVMEQ FASFKWSFIK QHWQFATSAA
GVCINFVIIM MLNVAYEKIA YLLTNLEYPR TESEWENSFA LKMFLFQFVN LNSSIFYIAF
FLGRFVGHPG NYNKLFNRWR LEECHPSGCL IDLCLQMGVI MFLKQIWNNF MELGYPLIQN
WWSRHKIKRG IHDASLPQWE NDWNLQPMNI HGLMDEYLEM VLQFGFTTIF VAAFPLAPLL
ALLNNIIEIR LDAYKFVTQW RRPLPARATD IGIWYGILEG IGILAVITNA FVIAITSDYI
PRLVYEYKYG PCADQLENGD NCLKGYVNNS LSFFDLSELG IGKSGYCRYR DYRGPPWSSK
PYEFTLQYWH ILAARLAFII VFEHLVFGIK SFIAFLIPDV PQDLYDRIRR EKYLVQEMMY
EAELEHLQQQ RKKCGQPVHH EWP
//