ID   A0A2Y9RPU7_TRIMA        Unreviewed;      1043 AA.
AC   A0A2Y9RPU7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=LOC101347636 {ECO:0000313|RefSeq:XP_023593588.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023593588.1};
RN   [1] {ECO:0000313|RefSeq:XP_023593588.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   RefSeq; XP_023593588.1; XM_023737820.1.
DR   AlphaFoldDB; A0A2Y9RPU7; -.
DR   STRING; 127582.A0A2Y9RPU7; -.
DR   InParanoid; A0A2Y9RPU7; -.
DR   OrthoDB; 534027at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF16; ANOCTAMIN-3; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        457..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        534..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        609..633
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        653..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        704..726
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        821..843
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        871..895
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        968..987
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          219..443
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          446..1011
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1043 AA;  121281 MW;  60D4A59B5BDF6B79 CRC64;
     MSAAMFELDN LSPGSSRQEH VSNSDFTLTC LTELSSDSSQ LELQHSNSVP DGLQKLCLSH
     HGLEKSAWAA EGKYQQGMNI SKSEMVKETS LKPSRRSLPC LAQSYTYSQS LSQSTSLFQS
     NESESQAPTS VTTVSIDKAA QVNAEENKKD SVLNCSFTDL SDFCLALEKD KDYTDESEHA
     NYDRSRLIRD SVCKDKPEPK PKSLPKNDMN YIASSGLLFK DGKKRIDYIL VYRKSNIQYD
     RRNTFEKNLR AEGLMLEKEP AVANTDIMFI KIHIPWDTLC KYAERLNIRM PFRKKCYFTD
     RRSKSMGRMK KNLKKIMKWM PQNPMALDKS AFPDLEELEC YTGPFSRARI HHFIINNKDT
     FFSNATRSRI VYHMLQRTKY ENGISKVGIC KLINNGAYEA AFPPHEGAYK SRQPIKTHGP
     QNNRHLLYER WARWGMWYKH QPLDLIRRYF GEKIGLYFAW LGWYTGMLIP AAIVGLCVFF
     YGLFTMNGSQ VSQEICAAAE VFMCPLCDKN CSLQRLNDSC IYAKVTYLFD NGGTVFFAIF
     MAIWATVFLE FWKRRRSILT YAWDLIEWEE EEETLRPQFE AKYYTMERVN PITGKPEPHQ
     PFSDKITRLL VSVSGIFFMI SLVITAVFAV VVYRLVVMEQ FASFKWSFIK QHWQFATSAA
     GVCINFVIIM MLNVAYEKIA YLLTNLEYPR TESEWENSFA LKMFLFQFVN LNSSIFYIAF
     FLGRFVGHPG NYNKLFNRWR LEECHPSGCL IDLCLQMGVI MFLKQIWNNF MELGYPLIQN
     WWSRHKIKRG IHDASLPQWE NDWNLQPMNI HGLMDEYLEM VLQFGFTTIF VAAFPLAPLL
     ALLNNIIEIR LDAYKFVTQW RRPLPARATD IGIWYGILEG IGILAVITNA FVIAITSDYI
     PRLVYEYKYG PCADQLENGD NCLKGYVNNS LSFFDLSELG IGKSGYCRYR DYRGPPWSSK
     PYEFTLQYWH ILAARLAFII VFEHLVFGIK SFIAFLIPDV PQDLYDRIRR EKYLVQEMMY
     EAELEHLQQQ RKKCGQPVHH EWP
//