ID A0A2Y9RQK7_TRIMA Unreviewed; 556 AA.
AC A0A2Y9RQK7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Flavin-containing monooxygenase {ECO:0000256|RuleBase:RU361177};
DE EC=1.-.-.- {ECO:0000256|RuleBase:RU361177};
GN Name=LOC101341349 {ECO:0000313|RefSeq:XP_004384163.1,
GN ECO:0000313|RefSeq:XP_023594219.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023594219.1};
RN [1] {ECO:0000313|RefSeq:XP_004384163.1, ECO:0000313|RefSeq:XP_023594219.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRNR:PIRNR000332, ECO:0000256|RuleBase:RU361177};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|PIRNR:PIRNR000332}.
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000256|ARBA:ARBA00009183,
CC ECO:0000256|PIRNR:PIRNR000332, ECO:0000256|RuleBase:RU361177}.
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DR RefSeq; XP_004384163.1; XM_004384106.2.
DR RefSeq; XP_023594219.1; XM_023738451.1.
DR GeneID; 101341349; -.
DR KEGG; tmu:101341349; -.
DR OrthoDB; 2079054at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0047822; F:hypotaurine dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000960; Flavin_mOase.
DR InterPro; IPR020946; Flavin_mOase-like.
DR InterPro; IPR002256; Flavin_mOase_4.
DR PANTHER; PTHR23023; DIMETHYLANILINE MONOOXYGENASE; 1.
DR PANTHER; PTHR23023:SF74; DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 4; 1.
DR Pfam; PF00743; FMO-like; 1.
DR PIRSF; PIRSF000332; FMO; 1.
DR PRINTS; PR00370; FMOXYGENASE.
DR PRINTS; PR01124; FMOXYGENASE4.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|PIRNR:PIRNR000332};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRNR:PIRNR000332};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|PIRNR:PIRNR000332}; Membrane {ECO:0000256|PIRNR:PIRNR000332};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|PIRNR:PIRNR000332};
KW NADP {ECO:0000256|ARBA:ARBA00022857, ECO:0000256|PIRNR:PIRNR000332};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000332};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
SQ SEQUENCE 556 AA; 63120 MW; 4E638D673353D3A1 CRC64;
MAKRVAVIGA GVSGLSSIKC CLDEDLEPIC FERSNDIGGL WKFTETSKDG MTRVYKSLVT
NVCKEMSCYS DFPFQEDYPN FMKQEKFWHY LQEFAEHFDL LKYIQFKTTV CSVTKCPDFS
VSGQWDVITE TEDKKDRAVF DAVMVCTGHF LNPRLPLESF PGIHNFKGHI LHSQEYKIPV
GFQDKRVLVI GLGNTGGDIA VELSRTAAQV LLSTRTGAWV VGRSSHGGYP FNMMITRRCY
NFIEQILPSC VLKWIQERQM NKIFNHENYG LSITKGKKSK IIVNDELPTC ILCGSVTMKT
SVKEFTETSA LFEDGTVEEN IDVVIFTTGY TFSFPFLEEP LKSLCSKKLF LYKKVFPSNL
EKATLAIIGL ISLKGSILSG TELQARWATR VFKGLCKLPP SQKLMADATK KEQLIKRNVI
KDNSEDKLDY IPYLDDLAAC IGTKPNVPLL FLKDPRLAWE VFFGPCTPYQ YRLMGPGKWN
GARNAILTQW DRTLKPLKTR VVHDSSKPAS MSHYLKVWGT LVLLASLLLL CKSSLCFKLL
WDKLQDRISP YQISIW
//
