ID A0A2Y9RQP2_TRIMA Unreviewed; 165 AA.
AC A0A2Y9RQP2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=T-cell surface glycoprotein CD3 zeta chain {ECO:0000256|ARBA:ARBA00020448};
DE AltName: Full=T-cell receptor T3 zeta chain {ECO:0000256|ARBA:ARBA00030941};
GN Name=LOC101345999 {ECO:0000313|RefSeq:XP_023594254.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023594254.1};
RN [1] {ECO:0000313|RefSeq:XP_023594254.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the CD3Z/FCER1G family.
CC {ECO:0000256|ARBA:ARBA00007280}.
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DR RefSeq; XP_023594254.1; XM_023738486.1.
DR AlphaFoldDB; A0A2Y9RQP2; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0098797; C:plasma membrane protein complex; IEA:UniProt.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR InterPro; IPR021663; CD3_zeta/IgE_Fc_rcpt_gamma.
DR InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR InterPro; IPR024128; T-cell_CD3_zeta.
DR PANTHER; PTHR10035; T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN; 1.
DR PANTHER; PTHR10035:SF2; T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN; 1.
DR Pfam; PF02189; ITAM; 2.
DR Pfam; PF11628; TCR_zetazeta; 1.
DR SMART; SM00077; ITAM; 3.
DR PROSITE; PS51055; ITAM_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..165
FT /note="T-cell surface glycoprotein CD3 zeta chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016052416"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 124..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 165 AA; 18825 MW; 87565585BADA2A9F CRC64;
MKWKVFVIMA VLQTQFPITE AQSFGMLDPK ICYLLDGILF IYGVVITALF LRAQFSRSAD
VPAYQPGSNQ LYNELNLGRR EEYDVLDKRR GWDPEMGGKQ RRKNPQEGVY NALQKNKMAE
AYSEIGLKGD NQRRRGKGPD GLYQGLSTAT KDTYDALHMQ TLPPR
//
