ID A0A2Y9RU91_TRIMA Unreviewed; 862 AA.
AC A0A2Y9RU91;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 1 {ECO:0000313|RefSeq:XP_023597186.1};
GN Name=LOC101350753 {ECO:0000313|RefSeq:XP_023597186.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023597186.1};
RN [1] {ECO:0000313|RefSeq:XP_023597186.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR RefSeq; XP_023597186.1; XM_023741418.1.
DR AlphaFoldDB; A0A2Y9RU91; -.
DR STRING; 127582.A0A2Y9RU91; -.
DR KEGG; tmu:101350753; -.
DR InParanoid; A0A2Y9RU91; -.
DR OrthoDB; 2970339at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15291; 7tmC_GABA-B-R1; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR002456; GPCR_3_GABA_rcpt_B1.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF76; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_023597186.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 492..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 499..777
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..842
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 862 AA; 96985 MW; B0386B989E83144A CRC64;
MSPLSSSPFS SGYPRPPTMG PGAPSPRVGW PLTLLVVMAA GVAPVWTSNS PHLLRPHPRV
PPHPSSERRA VYIGALFPMS GGWPGGQACQ PAVEMALEDV NSRRDILPDY ELKLIHHDSK
CDPGQATKYL YELLYNDPIK IILMPGCSSV STLVAEAARM WNLIVLSYGS SSPALSNRQR
FPTFFRTHPS ATLHNPTRVK LFEKWGWKKI ATIQQTTEVF TSTLDDLEER VKEAGIEITF
RQSFFSDPAV PVKNLKRQDA RIIVGLFYET EARKVFCEVY KERLFGKKYV WFLIGWYADN
WFKTYDPSIN CTVDEMTEAV EGHITTEIVM LNPANTRSIS NMTSQEFVEK LTKRLKRHPE
ETGGFQEAPL AYDAIWALAL ALNKTSGGGG HSGVRLEDFN YNNQTITDQI YRAMNSSSFE
GVSGHVVFDA SGSRMAWTLI EQLQGGSYKK IGYYDSTKDD LSWSKTDKWI GGSPPADQTL
VIKTFRFLSQ KLFISVSVLS SLGIVLAVVC LSFNIYNSHV RYIQNSQPNL NNLTAVGCSL
ALAAVFPLGL DGYHIGRSHF PFVCQARLWL LGLGFSLGYG SMFTKIWWVH TVFTKKEEKK
EWRKTLEPWK LYSTVGLLVG MDVLTLAIWQ IVDPLHRTIE TFAKEEPKED IDVSILPQLE
HCSSKKMNTW LGIFYGYKGL LLLLGIFLAY ETKSVSTEKI NDHRAVGMAI YNVAVLCLIT
APVTMILSSQ QDAAFAFASL AIVFSSYITL VVLFVPKMRR LITRGEWQSE AQDTMKTGSS
TNNNEEEKSR LLEKENRELE KIIAEKEERV SELRHQLQSR QQLRSRRHPP TPPDPSGVLP
RGPSEPPDRL SCDGSRVHLL YK
//
