ID   A0A2Y9RUQ2_TRIMA        Unreviewed;       950 AA.
AC   A0A2Y9RUQ2;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=IQ motif and SEC7 domain-containing protein 1 isoform X6 {ECO:0000313|RefSeq:XP_023598635.1};
GN   Name=LOC101343040 {ECO:0000313|RefSeq:XP_023598635.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023598635.1};
RN   [1] {ECO:0000313|RefSeq:XP_023598635.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the BRAG family.
CC       {ECO:0000256|ARBA:ARBA00006248}.
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DR   RefSeq; XP_023598635.1; XM_023742867.1.
DR   AlphaFoldDB; A0A2Y9RUQ2; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13318; PH_IQSEC; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR033742; IQSEC_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF327; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF16453; IQ_SEC7_PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT   DOMAIN          531..724
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          41..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          279..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        282..307
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..423
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..457
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..512
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   950 AA;  107202 MW;  120819C09446D07F CRC64;
     MCIFKQSTIR DQMVSVYLKA RRDREAGWMW QVGWKCVEGE APSSETGTSL DSPSAYHQGP
     LVPGASLSPD HYEHTSLGAY GLYSGPPGQQ QRTRRPKLQH STSILRKQAE EEAIKRSRSL
     SESYELSSDL QDKQVEMLER KYGGRLVTRH AARTIQTAFR QYQMNKNFER LRSSMSENRM
     SRRIVLSNMR MQFSFEGPEK VHSSYFEGKQ VSVTNDGSQL GVLVPSECGD LGKPAAIKSP
     ATSSDFADAI TELEDAFSRQ VKSLAESIDD ALNCRSLHAE EAPASDAARA RDTEPKPTLH
     GMDHHKLDEM TASYSDVTLY IDEEELSPPL PLSQVGERPS STESDLRLRA GGSSQDYWAL
     GHKDDKGDTD TSCRSTPSLE RPEQRLRGEH LPLLTIEPPS DSSVDLSDRS DRGSLKRQRA
     YERSLGGQEG SPKHGPHGGP PKGLPREEPE LRPRPPRPLD SHLAINGSAN RQSKSESDYS
     DGDNDSINST SNSNDTINCS SESSSRDSLR EQTLSKQTYH KETRNSWDSP AFSNDVIRKR
     HYRIGLNLFN KKPEKGVQYL IERGFVPDTP VGVAHFLLQR KGLSRQMIGE FLGNRQKQFN
     RDVLDCVVDE MDFSAMELDE ALRKFQAHIR VQGEAQKVER LIEAFSQRYC ICNPGVVRQF
     RNPDTIFILA FAIILLNTDM YSPNVKPERK MKLEDFVKNL RGVDDGEDIP REMLIGIYER
     IRKRELKTNE DHVSQVQKVE KLIVGKKPIG SLHHGLGCVL SLPHRRLVCY CRLFEVPDPN
     KPQKLGLHQR EIFLFNDLLV VTKIFQKKKN SVTYSFRQSF SLYGMQVLLF ENQYYPNGIR
     LTSAVPGADI KVLINFNAPN PQDRKKFTDD LRESIAEVQE MEKHRIETEL EKQKGVVRPS
     ISQCSSLKKE SGNGTLSRAC LDDSYASSEG LKRSALSSSL RDLSEAGVHH
//