ID A0A2Y9RWE0_TRIMA Unreviewed; 1887 AA.
AC A0A2Y9RWE0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ankyrin-2 isoform X10 {ECO:0000313|RefSeq:XP_023595968.1};
GN Name=LOC101354866 {ECO:0000313|RefSeq:XP_023595968.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023595968.1};
RN [1] {ECO:0000313|RefSeq:XP_023595968.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_023595968.1; XM_023740200.1.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 3.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 3.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 78..110
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 111..143
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 144..176
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 247..279
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 280..312
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 313..345
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 346..378
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 379..411
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 412..444
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 445..477
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 478..510
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 511..543
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 544..576
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 577..609
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 610..642
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 643..675
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 676..708
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 709..741
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 742..774
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 775..807
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 983..1171
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1173..1319
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1499..1583
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 19..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1472..1497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1620..1641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1706..1819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1842..1864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1706..1730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1737..1753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1784..1819
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1887 AA; 207968 MW; 9AC7EE03969811E0 CRC64;
MAHAAASIKK VREAELDEKE KILERERKKQ RKIPRERMER KRKSDSNASF LRAARAGNLD
KVVEYLKGGI DINTCNQNGL NALHLAAKEG HVGLVQELLG RGSAVDSATK KGNTALHIAS
LAGQAEVVKV LVKEGANINA QSQNGFTPLY MAAQENHIDV VKYLLENGAN QSTATEDGFT
PLAVALQQGH NQAVAILLEN DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKMM
ANRTTESGFT PLHIAAHYGN VNVATLLLNR GAAVDFTARN GITPLHVASK RGNTNMVKLL
LDRGGQIDAK TRDGLTPLHC AARSGHDQVV ELLLERGAPL LARTKNGLSP LHMAAQGDHV
ECVKHLLQHK APVDDVTLDY LTALHVAAHC GHYRVTKLLL DKRANPNARA LNGFTPLHIA
CKKNRIKVME LLVKYGASIQ AITESGLTPI HVAAFMGHLN IVLLLLQNGA SPDVTNIRGE
TALHMAARAG QVEVVRCLLR NGALVDARAR EEQTPLHIAS RLGKTEIVQL LLQHMAHPDA
ATTNGYTPLH ISAREGQVDV ASVLLEAGAA HSLATKKGFT PLHVAAKYGS LDVAKLLLQR
RAAADSAGKN GLTPLHVAAH YDNQKVALLL LEKGASPHAT AKNGYTPLHI AAKKNQMQIA
STLLNYGAET NIVTKQGVTP LHLASQEGHT DMVTLLLDKG ANIHTATKSG LTSLHLAAQE
DKVNVADILT KHGADQDAHT KLGYTPLIVA CHYGNVKMVN FLLKQGANVN AKTKNGYTPL
HQAAQQGHTH IINVLLQHGA KPNATTANGN TALAIAKRLG YISVVDTLKV VTEEVTTTTT
TITEKHKLNV PETMTEVLDV SDEEGDDTMT GDGGEYLRPE DLKELGDDSL PSSQFLDGMN
YLRYSLEGGR SDSLRSFSSD RSHTLSHASY LRDSAMIDDT VVIPSHQVST LAKEAERNSY
RLSWGTENLD NVALSSSPIH SGFLVSFMVD ARGGAMRGCR HNGLRIIIPP RKCTAPTRVT
CRLVKRHRLA TMPPMVEGEG LASRLIEVGP SGAQFLGKLH LPTAPPPLNE GESLVSRILQ
LGPPGTKFLG PVIVEIPHFA ALRGKERELV VLRSENGDSW KEHYCEYTED ELNEILNGMD
EVLDSPEDLE KKRICRIITR DFPQYFAVVS RIKQDSNLIG PEGGVLSSTV VPQVQAVFPE
GALTKRIRVG LQAQPMHSEL VKKILGNKAT FSPIVTLEPR RRKFHKPITM TIPVPKAASD
VMLNGFGGDA PTLRLLCSIT GGTTPAQWED ITGTTPLTFV NECVSFTTNV SARFWLIDCR
QIQESVTFAS QVYREIICVP YMAKFVVFAK SHDPIEARLR CFCMTDDKVD KTLEQQENFA
EVARSRDVEV LEGKPIYVDC FGNLVPLTKS GQHHIFSFFA FKENRLPLFV KVRDTTQEPC
GRLSFMKEPK STRGLVHQAI CNLNITLPVY TKESESDQEQ EEEIDMTSEK NPQDEQERIE
ERLAYIADHL GFSWTELARE LDFTEEQIHQ IRIENPNSLQ DQSHALLKYW LERDGKHATD
TGLIECLTKI NRMDIVHLME ASTEPFQERI SHSYAEIEQT ITLDHSEGFS VLQEELCTAQ
HKQKEEQPES KESETCDCPP IVSEEDISVG YSMFQDYIPK TEGDTSAAEL LSQTDKEQVQ
QDFSGKMQDL TEESSLEHQQ EYFVTTPGTE VSETLKSPVV SGSPSKIPEE ISTPSEEERP
YLQTPTSSEW GGSPIVQEPE ESPVQREESS PRRTSLVIVE SADDQPRIFE RPDEDVAFQK
GDDMPDIPPE TVTEEKYTDE HGHTVVKKVT RKIIRRYVSS DGTEKEEITM QGMPQEPVNI
EEGDDYSKVI KRVVLKSDTE QSEDNDE
//
