ID A0A2Y9RWQ5_TRIMA Unreviewed; 2097 AA.
AC A0A2Y9RWQ5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Dedicator of cytokinesis protein 9 isoform X7 {ECO:0000313|RefSeq:XP_023596093.1};
GN Name=LOC101351106 {ECO:0000313|RefSeq:XP_023596093.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023596093.1};
RN [1] {ECO:0000313|RefSeq:XP_023596093.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_023596093.1; XM_023740325.1.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT DOMAIN 174..281
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 640..818
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1606..2059
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 290..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1243..1283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1942..1969
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 290..306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2097 AA; 239017 MW; A332AF33980FF0D5 CRC64;
MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE PLDYENVIVQ
KKTQILNDCL REMLLFPYDD FQTAILRRQG RYMCSTVPAN AEQEAQSLFV TECIKTYNSD
WHLVNYKYED YSGEFRQLPN KVAKLDKLPV HVYEVDEEVD KDEDAASLGS QKGGITKHGW
LYKGNMNSAI SVTMRSFKRR FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ
NNKVRRFAFE LKMQDKSSYL LAADSEMEME EWIATLNKIL QLNFEAAMQE KRNGDSHEDD
EQSKLEGSGS GLDSYLPEFA KSTREAEIKL KSESRVKLFH LDPDAQKLDY PSAEPEVKPF
EEKFGKRILV RCNDLSFNLQ CCVAENEEGP TTNVEPFFVT LSLFDIKYNR KISADFHVDL
NHSSVRQMLA TTPPALMNGG RQTSPVLQDV LQEAAMQYPK QGIFSVTCPH PDIFLVARIE
KVLQGSITHC AEPYMKSSDS SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL
DKNARFSALY KQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV
NSSYLPMKQF ETCTKTPITF EVEEFVPCIP KHTQPYTIYN NHFYVYPKYL KYDSQKSFAK
ARNIAVCIEF KDSDEEDAQP LKCIYGRPGG PVFTRSAFAT VLHHHQNPEF YDEIKIELPT
QLHEKHHLLF TFFHVSCDNS SKGSTKKKDV VETQVGYSWL PLLKDGRVVT NEQHAPVSAN
LPSGYLGYQE LGMGRHYGPE IKWVDGGKPL LKVSTHLVST VYTQDQHLHN FFQYCQKTES
GAQALGNELV KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA
QCHEEGLESH LRSYVKYAYK AEPYVASKYK TVHEELTKSM TTILKPSADF LTSNKLLKYS
WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV VNMLMPHITQ KFRDNPEASK
NANHSLAVFI KRCFTFMDRG FVFKQINNYI SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP
LNLPMPFGKG RIQRYQDLQL DYALTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL
KNLLIKHSFD DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NSGSTVKDES
LNLPAANPLV TPQKSGNTLD NSLHKDLFGA ISGIASPYTT STPNISSVRN ADSRGSLIST
DSGNSLPERN SEKSNSLDKH QQSGALGNSV VRCDKLDQSE IKSLLMCFLY ILKSMSDDAL
FTYWNKASTS ELKDFFTISE VCLHQFQYMG KRYIARAGML HGRLQPLSSL DNALAVNHSY
GHSDADVLHQ SLLEANIATE VCLTALDTLS LFTLAFKNQL LADHGHNPLM KKVFDVYLCF
LQKHQSETAL KNVFTALRSL IYKFPSTFYE GRADMCAALC YEILKCCNSK LSSIRTEASQ
LLYFLMRNNF DYTGKKSFVR THLQVIISVS QLIADVVGIG GTRFQQSLSI INNCANSDRL
IKHTSFSSDV KDLTKRIRTV LMATAQMKEH ENDPEMLVDL QYSLAKSYAS TPELRKTWLD
SMARIHVKNG DLSEAAMCYV HVTALVAEYL TRKEADTALR REPPLLPHSH SACQRRSQGG
MFRQGCTAFR VITPNIDEEA SMMEDVGMQD VHFNEDVLTE LLEQCADGLW KAERYELIAD
IYKLIIPVYE KRRDFERLAH LYDTLHRAYS KVTEVMHSGR RLLGTYFRVA FFGQGFFEDE
DGKEYIYKEP KLTPLSEISQ RLLKLYSDKF GSENVKMIQD SGKVNPKDLD SKYAYIQVTH
VIPFFDEKEL QERKTDFERS HNIRRFMFEM PFTQTGKRQG GVAEQCKRRT VLTAIHCFPY
VKKRIPVMYQ HHTDLNPIEV AIDEMSKKVA ELRQLCASAE VDMIKLQLKL QGSVSVQVNA
GPLAYARAFL DDTNTKRYPD NKVKLLKEVF RQFVEACGQA LAVNERLIKE DQLEYQEEMK
ANYREMAKEL SEIMHEQICP LEEKSSVLPN SLHIFNAISG TPTSTVVHGM TSSSSVV
//
