ID A0A2Y9RWW5_PHYMC Unreviewed; 1019 AA.
AC A0A2Y9RWW5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Adhesion G-protein coupled receptor G2 isoform X3 {ECO:0000313|RefSeq:XP_023971046.1};
GN Name=ADGRG2 {ECO:0000313|RefSeq:XP_023971046.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023971046.1};
RN [1] {ECO:0000313|RefSeq:XP_023971046.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023971046.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_023971046.1; XM_024115278.3.
DR AlphaFoldDB; A0A2Y9RWW5; -.
DR Proteomes; UP000248484; Chromosome 21.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15444; 7tmB2_GPR64; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF264; ADHESION G-PROTEIN COUPLED RECEPTOR G2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_023971046.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 627..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 786..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 836..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 862..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 630..885
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 339..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 111733 MW; B43AF2CC51E22D77 CRC64;
MLFSGGQCGH VGRPEELLLT FKIFLVIICL HVTMVTSLEE HADNSSLLSP SAESSLVGFV
PYSNEVETTS LNDATSSVLS TLNKTEKTKI TIVKTFNASG VKPQRNICNL SSICNDSAFF
RGEIMLQYDE ESNVTQQNQV MANGTSTGIL SLRELKRSEL NKTLQTLSET YFIVCATAET
QSTLNCTFTI KLHKTMNIRA VMESLQTVKI RPMEQCCCPV SFPCPSSPEE LEKLQCDLQD
PVVCLARHPH GPPFSSSSNS IPVAPQATTV SQTSSAFSFA EPLAHPPVIQ SPHSPTTVIP
LSSPQPSVPI ASSPAIDMLP QSGAVSSPVP PTDLSHTLPP VKSLPPSPTA SAPVTVNTTS
IPPNETEIVH TSSISVSELE NQVSWMEKVL SLGSVEPNLA GQMINQVSKL LHSPPTLLAP
LAQRLLKVVD DIGLQLNFST KTISLTSPSL ALAVIRVNAS NFDTTTFAAQ DPANLQVSLE
TQAPENSIGV ITLPSSLMSN LPANDVELAS RVQFNFFETP ALFQDPALEN VSLISYVISS
SVANLTVKNL TRNVTVTLKH IHRSQDDLTV RCVFWDLGRN GGRGGWSSDG CSIKDRRLNE
TTCTCSHLTS FGVLLDLSRT SLPPAQIMAL TFITYIGCGL SSIFLSVTLV TYIAFEKIRR
DYPSKILIQL CAALLLLNLV FLLDSWIALY DIRGLCISVA IFLHYFLLVS FTWMGLEAFH
MYLALVKVFN TYIRKYILKF CIVGWGVPAV VVTIVLIISP DNYGLGSYGK FPNGSPDDFC
WINSNAVFYI TVVGYFCVIF LLNVSMFIVV LVQLCRIKKK KQLGAQRKTS IQDLRSVAGL
TFLLGITWGF AFFAWGPVNV TFMYLFAIFN TLQGFFIFIF YCVAKENVRK QWRRYLCCGK
LRLAENSDWS KTATNGLKKQ TVNQGVSSSS NSLQSNSNST QSTTLLVNND CSGLTSGNAN
ASTEKNGFSF SLQNGDVCLH DFTGKQHMFN EKEDSCNGKN RIALRRTTKR GSLHFIEQM
//
