ID A0A2Y9RY11_TRIMA Unreviewed; 508 AA.
AC A0A2Y9RY11;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Fibroblast growth factor receptor substrate 2 isoform X2 {ECO:0000313|RefSeq:XP_023596578.1, ECO:0000313|RefSeq:XP_023596579.1};
GN Name=LOC101350670 {ECO:0000313|RefSeq:XP_023596578.1,
GN ECO:0000313|RefSeq:XP_023596579.1, ECO:0000313|RefSeq:XP_023596580.1,
GN ECO:0000313|RefSeq:XP_023596581.1, ECO:0000313|RefSeq:XP_023596582.1,
GN ECO:0000313|RefSeq:XP_023596583.1, ECO:0000313|RefSeq:XP_023596584.1,
GN ECO:0000313|RefSeq:XP_023596585.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023596578.1};
RN [1] {ECO:0000313|RefSeq:XP_023596578.1, ECO:0000313|RefSeq:XP_023596579.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012413859.1; XM_012558405.1.
DR RefSeq; XP_023596578.1; XM_023740810.1.
DR RefSeq; XP_023596579.1; XM_023740811.1.
DR RefSeq; XP_023596580.1; XM_023740812.1.
DR RefSeq; XP_023596581.1; XM_023740813.1.
DR RefSeq; XP_023596582.1; XM_023740814.1.
DR RefSeq; XP_023596583.1; XM_023740815.1.
DR RefSeq; XP_023596584.1; XM_023740816.1.
DR RefSeq; XP_023596585.1; XM_023740817.1.
DR GeneID; 101350670; -.
DR KEGG; tmu:101350670; -.
DR OrthoDB; 2996885at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01202; PTB_FRS2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR038742; FRS2_PTB.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR PANTHER; PTHR21258:SF40; FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2; 1.
DR Pfam; PF02174; IRS; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 4: Predicted;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Receptor {ECO:0000313|RefSeq:XP_023596578.1,
KW ECO:0000313|RefSeq:XP_023596579.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT DOMAIN 13..115
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 121..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 508 AA; 57086 MW; 61DCBFB6BB5CDE92 CRC64;
MGSCCSCPDK DTVPDNHRNK FKVINVDDDG NELGSGIMEL TDTELILYTR KRDSVKWHYL
CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CARAEELFNM LQEIMQNNSI NVVEEPVVER
NNHQTELEVP RTPRTPTTPG FAAQNLPNGY PRYPSFGDGS SHPSSRHPSV GSARLPSVGE
ESTHPLLVAE EQVHTYVNTT GVQEERKNRT SVHVPLEARV SNAESNMPKE EPSSIEDRDP
QILLEPEGVK FVLGPTPVQK QLMEKEKLEQ LGRDQVSGSG ANNTEWDTGY DSDERRDAPT
VNKLVYENIN GLSIPSASGV RRGRLTSTST SDTQNINNSA QRRTALLNYE NLPSLPPVWE
ARKLSRDEDD NLGPKTPSLN GYHNNLDPMH NYVNTENVTV PASAHKIEYS RRRDCTPTVF
NFDIRRPSLE HRQLNYIQVD LEGGSDSDNP QTPKTPTTPL PQTPTRRTEL YAVIDIERTA
AMSNLQKALP RDDGTSRKTR HNSTDLPM
//
