ID A0A2Y9S085_PHYMC Unreviewed; 576 AA.
AC A0A2Y9S085;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=BTB/POZ domain-containing protein KCTD7 {ECO:0000256|ARBA:ARBA00040260};
GN Name=TMEM248 {ECO:0000313|RefSeq:XP_023970902.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023970902.1};
RN [1] {ECO:0000313|RefSeq:XP_023970902.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023970902.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_023970902.1; XM_024115134.3.
DR AlphaFoldDB; A0A2Y9S085; -.
DR Proteomes; UP000248484; Chromosome 14.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18366; BTB_POZ_KCTD7; 1.
DR Gene3D; 1.10.246.120; -; 1.
DR Gene3D; 1.20.5.4770; -; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR037191; VPS9_dom_sf.
DR InterPro; IPR002653; Znf_A20.
DR PANTHER; PTHR14499:SF122; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD7; 1.
DR PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF01754; zf-A20; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00259; ZnF_A20; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS51036; ZF_A20; 1.
PE 4: Predicted;
KW Membrane {ECO:0000313|RefSeq:XP_023970902.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transmembrane {ECO:0000313|RefSeq:XP_023970902.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00451}.
FT DOMAIN 304..338
FT /note="A20-type"
FT /evidence="ECO:0000259|PROSITE:PS51036"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 576 AA; 66727 MW; 0822A94854BFA083 CRC64;
MVVVTGREPD SRRPDGAMSS SDAEDDFLEP ATPTATQAGH ALPLLPQEFP EVVPLNIGGA
HFTTRLSTLR RYEDTMLAAM FSGRHYIPTD AEGRYFIDRD GAHFGDVLNF LRSGDLPPRE
RVRAVYKEAQ YYAIGPLLEQ LENMQPLKGE KVRQAFLGLM PYYKDHLERI VEIARLRAVQ
RKARFAKLKV CVFKEEMPIT PYECPLLSSL RFERSESDGQ LFEHHCEVDV SFGPWEAVAD
VYDLLHCLVT DLSAQGLTVD HQCIGVCDKH LINHYYCKRP IYEFKITWWK KMSLKSERRG
IHVDQSELLC KKGCGYYGNP AWQGFCSKCW REEYHKARQK QIQEDWELAE RLQREEEEAF
ASSQSSQGAQ SLTFSKFEEK KTNEKTRKVT TVKKFFSASS RVGSKKAEIQ EPKAPSPSIN
RQTSIETDRV SKEFIEFLKT FHKTGQEIYK QTKLFLESMH YKRDLSIEEQ SECTQDFYQN
VAERMQTRGK VPPERVEKIM DQIEKYIMTR LYKYVFCPET TDDEKKDLAI QKRIRALHWV
TPQMLCVPVN EEIPEVSDMV VKAITGIIQQ KCNTKV
//
