ID   A0A2Y9S0G7_TRIMA        Unreviewed;      1042 AA.
AC   A0A2Y9S0G7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=LOW QUALITY PROTEIN: neurofilament heavy polypeptide {ECO:0000313|RefSeq:XP_023597538.1};
GN   Name=LOC101351185 {ECO:0000313|RefSeq:XP_023597538.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023597538.1};
RN   [1] {ECO:0000313|RefSeq:XP_023597538.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   RefSeq; XP_023597538.1; XM_023741770.1.
DR   STRING; 127582.A0A2Y9S0G7; -.
DR   KEGG; tmu:101351185; -.
DR   InParanoid; A0A2Y9S0G7; -.
DR   OrthoDB; 4640531at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005883; C:neurofilament; IEA:InterPro.
DR   GO; GO:0061564; P:axon development; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR010790; DUF1388.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR033183; NF-H.
DR   PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR   PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR   Pfam; PF07142; DUF1388; 4.
DR   Pfam; PF00038; Filament; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT   DOMAIN          94..410
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          455..1042
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          175..223
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          294..381
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        459..479
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        480..640
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        705..1042
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1042 AA;  114864 MW;  2D5BFBFDC5A7CE9F CRC64;
     MMSFGGADAL LGAPFPPLPG GGGLYYALGR KGGAGGARSA AGSSSGFHSW ARTSASSVSA
     SPGRFRGAAA VSSTDSLDTL SNGPEGCVVA ARSEKEQLQV LNDRFAGYID KVRQLEAHNR
     SLEGEAAALR QQQAGRAAMG ELYERELREM RGAVLRLGAA RGQLRLEQDH LLEDIAHVRQ
     RLDDEARQRE EAEAAARALA RFAQDAEAAR GELQKKAQAL QEECGYLRRH HQEEVGELLR
     QIQGCGAAQA QAQAEARDAL KCDVTSALRE IRAQLEGHTV QSTLQSEEWF RVRLDRLSEA
     AKVNTDAMRS AQEEITEYRR QLQSRTTELE ALKGTKDSLE RQRSELEERH QADIASYQEA
     IQQLDTELRN TKWEMAAHLR EYQDLLNVKM ALDIEIAAYR KLLEGEEYRI GFGPSPLSLP
     EVFPKVPSTT THIKVKSEEK IKVVEKSEKE TVILEEQMEE VQVTEEVTEE EEKEAKEEEG
     KEGEEEKAEK GEEEAKSPPA EEAISPEKEV KSPAKEEAKS PAEAKSPEKA KSPVKEEAPS
     PAKVKSPEKA KSPLKEEAKS PAEVKSPEKA ETPVKEEAKS PAEVKSPEKA KSPVKEEAKS
     PVKEEAKSPA EVKSPEKAKT PVKEEAKSPT EVKSPEKAKT PVKEXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XPEKAKTPVK EEAKSPTEVK
     SPEKAKTPVK EEAKSPAEVK SPEKAKSPVK EEAKSPEKAK TLDVKSPEAK TPVKEEIRSP
     ADIKSPEKPK TPVKEEVKSP EKVKSPVKED AKAPEKEVPK KEEAKSPMKE EKPQEVKVKE
     PPKKVEEEKA PATPKTEEKD SKKDEVPKKG APKPEVEEKK EPTVEKPKES KVEAKKEETE
     DKKKAATPEK EAPAKVEVKE EAKPKEKVEV AKKEPDDAKA KEPGKPAAKE PEKPKKEEAP
     AAPEKKDTKE EKATEAKKPE EKPKTETKAK EEEKPVAKEP SKEAPKPSKP EMEKAEKSSS
     TDQKDSRPPE KAPEDKAPKG EK
//