ID   A0A2Y9S159_PHYMC        Unreviewed;       398 AA.
AC   A0A2Y9S159;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=E3 ubiquitin-protein ligase RNF149 {ECO:0000313|RefSeq:XP_023972346.1};
GN   Name=RNF149 {ECO:0000313|RefSeq:XP_023972346.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023972346.1};
RN   [1] {ECO:0000313|RefSeq:XP_023972346.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023972346.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_007130305.1; XM_007130243.1.
DR   RefSeq; XP_023972346.1; XM_024116578.3.
DR   AlphaFoldDB; A0A2Y9S159; -.
DR   STRING; 9755.ENSPCTP00005016621; -.
DR   Ensembl; ENSPCTT00005018333; ENSPCTP00005016621; ENSPCTG00005011779.
DR   KEGG; pcad:102976818; -.
DR   InParanoid; A0A2Y9S159; -.
DR   OrthoDB; 5474929at2759; -.
DR   Proteomes; UP000248484; Chromosome 12.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0043409; P:negative regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR   CDD; cd02122; PA_GRAIL_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR46539; E3 UBIQUITIN-PROTEIN LIGASE ATL42; 1.
DR   PANTHER; PTHR46539:SF30; RING FINGER PROTEIN 149; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           33..398
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015996549"
FT   TRANSMEM        199..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          267..308
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          50..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   398 AA;  43196 MW;  F98F11DD5589F3D5 CRC64;
     MAWRRRRPEA RGGARGALAL LALVLCAPGA RGRALEWYSA VVSTEYVDPQ TNRSVRSVSE
     SGRFGESSPK EGARGLVGVP RAEDRDPEGC APRTRFLVPG GREAAPWVAL VARGGCTFKD
     KVLAAARRNA SAVVLYNEER HGNLTAPMSH AGTGNIVVIM VSYPKGREIV DLVQKDIPVT
     MTIGLGTRHV QEFISGQSVV FVAIAFITMM IISLAWLIFY YIQRFLYTGS QFGSQSHRKE
     TKKLIGQLPL HTVKHGEKGI DVDAESCAVC IENFKGKDVI RILPCKHIFH RICIDPWLLD
     HRTCPMCKLD VIKALGYWGE LEDVQETPAP ESPPGGVSTA DLSLTLPDGD RSDAGSSSLP
     TTSDSTPPCE ASFKEDAGEN TALLEPSRSD PQCEGPVS
//