ID A0A2Y9S3U7_PHYMC Unreviewed; 761 AA.
AC A0A2Y9S3U7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cullin-4A isoform X1 {ECO:0000313|RefSeq:XP_023973213.1};
GN Name=CUL4A {ECO:0000313|RefSeq:XP_023973213.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023973213.1};
RN [1] {ECO:0000313|RefSeq:XP_023973213.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023973213.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR RefSeq; XP_023973213.1; XM_024117445.3.
DR AlphaFoldDB; A0A2Y9S3U7; -.
DR STRING; 9755.ENSPCTP00005029927; -.
DR Ensembl; ENSPCTT00005032894; ENSPCTP00005029927; ENSPCTG00005021256.
DR InParanoid; A0A2Y9S3U7; -.
DR OrthoDB; 21270at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000248484; Chromosome 13.
DR GO; GO:0031464; C:Cul4A-RING E3 ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0160072; F:ubiquitin ligase complex scaffold activity; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0030097; P:hemopoiesis; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0030853; P:negative regulation of granulocyte differentiation; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:2000001; P:regulation of DNA damage checkpoint; IEA:Ensembl.
DR GO; GO:2000819; P:regulation of nucleotide-excision repair; IEA:Ensembl.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:Ensembl.
DR GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR GO; GO:0140627; P:ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; IEA:Ensembl.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF68; CULLIN-4A; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 406..634
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 761 AA; 87911 MW; 9247E52FAC1606AB CRC64;
MADETPRKGS FSALVGHTNG LTKPASLAAA AVTSKPGAAG GSKKLVIKNF RDRPKLPDNY
TQDTWQKLHE AVKAIQSSTS IRYNLEELYQ AVENLCSHKV SPVLYQQLRQ VCEGHVQAQI
LQFREDSLDS VLFLKKINTC WQDHCRQMIM IRSIFLFLDR TYVLQNSMLP SIWDMGLELF
RNHIISDKVV QTKTIDGTLL LIERERSGEA VDRSLLRSLL GMLSDLQVYK DSFELKFLEE
TNCLYAAEGQ RLMQEREVPE YLNHVSKRLG EEGDRVITYL DHSTQKPLIA CVEKQLLGEH
LTAILQKGLD HLLDENRVPD LTQMYQLFSR VRGGQQALLQ HWSEYIKTFG TTIVINPEKD
KDMVQDLLDF KDRVDHVIEV CFQRNEKFIN LMKESFESFI NKRPNKPAEL IAKHVDSKLR
AGNKEATDEE LERILDKIMI LFRFIHGKDV FEAFYKKDLA KRLLVGKSAS VDAEKSMLSK
LKHECGAAFT SKLEGMFKDM ELSKDIMVHF KQYMQNQSDP GSIDLTVNIL TMGYWPTYTP
MEVHLTPEMI KLQEVFKTFY LGKHSGRKLQ WQTTLGHAVL KAEFKEGKKE FQVSLFQTLV
LLMFNEGDGF GFEDIKMATG IEDSELRRTL QSLACGKARV LIKSPKGREV EDGDRFIFNG
EFKHKLFRIK INQIQMKETV EEQVSTTERV FQDRQYQIDA AIVRIMKMRK TLGHNLLVSE
LYNQLKFPVK PGDLKKRIES LIDRDYMERD QDSPNQYRYV A
//
