ID   A0A2Y9S865_PHYMC        Unreviewed;       793 AA.
AC   A0A2Y9S865;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Kinesin-associated protein 3 {ECO:0000313|RefSeq:XP_023972435.1};
GN   Name=KIFAP3 {ECO:0000313|RefSeq:XP_023972435.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023972435.1};
RN   [1] {ECO:0000313|RefSeq:XP_023972435.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023972435.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_023972435.1; XM_024116667.1.
DR   AlphaFoldDB; A0A2Y9S865; -.
DR   STRING; 9755.ENSPCTP00005005931; -.
DR   Ensembl; ENSPCTT00005006529; ENSPCTP00005005931; ENSPCTG00005004091.
DR   KEGG; pcad:102974645; -.
DR   InParanoid; A0A2Y9S865; -.
DR   OrthoDB; 5480163at2759; -.
DR   Proteomes; UP000248484; Chromosome 4.
DR   GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0000794; C:condensed nuclear chromosome; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016939; C:kinesin II complex; IEA:Ensembl.
DR   GO; GO:1990075; C:periciliary membrane compartment; IEA:Ensembl.
DR   GO; GO:0032391; C:photoreceptor connecting cilium; IEA:Ensembl.
DR   GO; GO:0001917; C:photoreceptor inner segment; IEA:Ensembl.
DR   GO; GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
DR   GO; GO:0005876; C:spindle microtubule; IEA:Ensembl.
DR   GO; GO:0120170; F:intraciliary transport particle B binding; IEA:Ensembl.
DR   GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
DR   GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR   GO; GO:0010659; P:cardiac muscle cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0007017; P:microtubule-based process; IEA:Ensembl.
DR   GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0007406; P:negative regulation of neuroblast proliferation; IEA:Ensembl.
DR   GO; GO:0070244; P:negative regulation of thymocyte apoptotic process; IEA:Ensembl.
DR   GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR   GO; GO:0046587; P:positive regulation of calcium-dependent cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR   GO; GO:0070242; P:thymocyte apoptotic process; IEA:Ensembl.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR008658; KAP3.
DR   PANTHER; PTHR15605:SF2; KINESIN-ASSOCIATED PROTEIN 3; 1.
DR   PANTHER; PTHR15605; KINESIN-ASSOCIATED PROTEINS; 1.
DR   Pfam; PF05804; KAP; 1.
DR   SMART; SM00185; ARM; 3.
DR   SMART; SM01297; KAP; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   REPEAT          589..633
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REGION          101..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   793 AA;  91293 MW;  D9BAFBA8CE9BB84D CRC64;
     MQGEDARYLK RKVKGGNIDV HPSEKALIVQ YEVEATILGE MGDPMLGERK ECQKIIRLKS
     LNANTDITSL ARKVVEECKL IHPSKLNEVE QLLYYLQNRR DSASGKEKKE KSSKPKDPPP
     FEGMEIDEVA NINDMDEYIE LLYEDIPDKV RGSALILQLA RNPDNLEELL LNETALGALA
     RVLREDWKQS VELATNIIYI FFCFSSFSQF HGLITHYKIG ALCMNIIDHE LKRHELWQEE
     LSKKKKTVDE DPENQTLRKD YEKTFKKYQG LVVKQEQLLR VALYLLLNLA EDTRTELKMR
     NKNIVHMLVK ALDRDNFELL ILVVSFLKKL SIFMENKNDM VEMDIVEKLV KMIPCEHEDL
     LNITLRLLLN LSFDTGLRNK MVQVGLLPKL TALLGNENYK QIAMCVLYHI SMDDRFKSMF
     AYTDCIPQLM KMLFECSDER IDLELISFCI NLAANKRNVQ LICEGNGLKM LMKRALKFKD
     PLLMKMIRNI SQHDGPTKNL FIDYVGDLAA QISNDEEEEF VIECLGTLAN LTIPDLDWEL
     VLKEYKLVPY LKDKLKPGAA EDDLVLEVVI MIGTVSMDDS CAALLAKSGI IPALIELLNA
     QQEDDEFVCQ IIYVFYQMVF HQATRDVIIK ETQAPAYLID LMHDKNNEIR KVCDNTLDII
     AEYDEEWAKK IQSEKFRWHN SQWLEMVESR QMDESEQYLY GDDRIEPYIH EGDILERPDL
     FYSSDGLVAS EGAMSPDFFN DYHLQNGDVA GQHSFPGSLG MDGFGQSVGI LGRPATAYGF
     RPDEPYYYGY GSR
//