ID A0A2Y9S8Z4_PHYMC Unreviewed; 1166 AA.
AC A0A2Y9S8Z4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=TBC1 domain family member 1 isoform X14 {ECO:0000313|RefSeq:XP_023972279.1};
GN Name=TBC1D1 {ECO:0000313|RefSeq:XP_023972279.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023972279.1};
RN [1] {ECO:0000313|RefSeq:XP_023972279.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023972279.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023972279.1; XM_024116511.2.
DR AlphaFoldDB; A0A2Y9S8Z4; -.
DR Ensembl; ENSPCTT00005027187; ENSPCTP00005024672; ENSPCTG00005017560.
DR KEGG; pcad:102984927; -.
DR Proteomes; UP000248484; Chromosome 7.
DR CDD; cd00934; PTB; 1.
DR CDD; cd01269; PTB_TBC1D1_like; 1.
DR Gene3D; 1.10.10.2750; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR021785; DUF3350.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF18; TBC1 DOMAIN FAMILY MEMBER 1 ISOFORM X1; 1.
DR Pfam; PF11830; DUF3350; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00462; PTB; 2.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 293..372
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 798..992
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 208..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1045..1126
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 562..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1166 AA; 131790 MW; DF0366384842B053 CRC64;
MDTITFTARK HPFPSEVSVE FSLQLVGFLP VHSLTTMPML PWVVAEVRRL SEQSSKKESG
TKQVHLCVSP SGLRCEPEPG KSQQWDPLIC SSIFECKPQR VHKLIHNSHD PSYFACLIKD
DAANQQSICY VFKADGQTKV PEIISSIRQA GKIARQEELR CPSEFDDTFA KKFEVLFCGR
VAVAHRKAPP ALIDECIEGF SHVSGGGFSS DQLRAAPQPP GDRERGPRPM RKSFSQPGLR
SLAFRKEFQD AGLRSSSFFS SFEENGIENH LISGHNIVQP TDIEENRTML FTIGQSEVYL
ISPDTKKIAL EKNFKEISFC SQGIRHVDHF GFICRESLGG GAFHFVCYVF QCTNEALVDE
IMMTLKQAFT VAAVQQTAKA TAQLCEGCPL QGLHKLCERI EGMNSSKTKL ELQKHLTTLT
NQEQATIFEE VQKLRPRNEQ RENELIVSFL RCLYEEKQKV HVHIGEIKQT SQIAAENIGS
ELPSSATRFR LDMLKNKAKR SLTESLESIL SRGNKARGLQ EHSVSLDLDS SVSSALSNTS
KEPSVCEKEA LPISESSFRL LGSSDDLSSD SESHATEEPA LLSPQQGFRR RANTLSHVPV
ECQQPLQQAQ GSPGVSQRKL VRYHSVSTET PHERKDFESK ASHLGDASGT PVKTRRHSWR
QQIFLRVATP QKACDSPGRH EDYSELGELP PRSPLEPVCE DGPFGPVPEE KKRTSRELRE
LWQKAILQQI LLLRMEKENQ KLQASENDLL NKRLKLDYEE ITPCLKEVTT VWEKMLTTPG
RSKIKFDMEK MHSAVGQGVP RHHRGEIWKF LAEQYHLKHP FPSKQQPKDT PYKELLKQLT
SHQHSILIDL GRTFPTHPYF SAQLGAGQLS LYNILKAYSL LDQEVGYCQG LSFVAGILLL
HMGEEEAFNM LKFLMFDMGL RKQYRPDMII LQIQMYQLSR LLHDYHRDLY NHLEEHEIGP
SLYAAPWFLT VFASQFPLGF VARVFDMIFL QGSEVTFKVA LSLLGSHKPL ILQHENLETI
VDFIKSTLPN LGLVQMEKTI SQVFVMDISK QLQAYEVEYH VLQEELIDSS PLSDNQRMDR
LEKTNSSLRK QNLDLLEQLQ VANGRIQSLE ATIEKLLTSE SKLKQATLAL ELERSALLQA
VERLQGQTAE LGGPEPDPTL PEPAGH
//
