ID A0A2Y9SAV6_PHYMC Unreviewed; 839 AA.
AC A0A2Y9SAV6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|ARBA:ARBA00017947, ECO:0000256|PIRNR:PIRNR007949};
GN Name=VPS16 {ECO:0000313|RefSeq:XP_023972924.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023972924.1};
RN [1] {ECO:0000313|RefSeq:XP_023972924.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023972924.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport and
CC autophagic pathways. Believed to act as a core component of the
CC putative HOPS and CORVET endosomal tethering complexes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Late endosome membrane {ECO:0000256|PIRNR:PIRNR007949}; Peripheral
CC membrane protein {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Lysosome membrane
CC {ECO:0000256|PIRNR:PIRNR007949}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Note=Cytoplasmic, peripheral membrane
CC protein associated with late endosomes/lysosomes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SIMILARITY: Belongs to the VPS16 family.
CC {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
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DR RefSeq; XP_007127204.1; XM_007127142.1.
DR RefSeq; XP_023972924.1; XM_024117156.3.
DR AlphaFoldDB; A0A2Y9SAV6; -.
DR STRING; 9755.ENSPCTP00005008491; -.
DR Ensembl; ENSPCTT00005009348; ENSPCTP00005008491; ENSPCTG00005005686.
DR Ensembl; ENSPCTT00005009447; ENSPCTP00005008573; ENSPCTG00005005686.
DR KEGG; pcad:102982871; -.
DR Proteomes; UP000248484; Chromosome 14.
DR GO; GO:0033263; C:CORVET complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0097352; P:autophagosome maturation; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR InterPro; IPR016534; VPS16.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR InterPro; IPR006926; Vps16_N.
DR PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
DR Pfam; PF04841; Vps16_N; 1.
DR PIRSF; PIRSF007949; VPS16; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|PIRNR:PIRNR007949};
KW Lysosome {ECO:0000256|PIRNR:PIRNR007949};
KW Membrane {ECO:0000256|PIRNR:PIRNR007949};
KW Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT DOMAIN 4..420
FT /note="Vps16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04841"
FT DOMAIN 517..835
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
FT COILED 349..376
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 839 AA; 94823 MW; 5223E6C433D3B3C3 CRC64;
MDCYTANWNP LGDSAFYRKY ELYSMDWDLK EELRDCLVAA APYGGPIALL RNPGRKEKPA
SARPVLEIYS ASGVPLASLL WKSGPMVSLG WSAEEELLCV QEDGVVLVYG LHGDFRRHFS
MGNEVLQNRV LDARIFHTEF GSGVAILTGA HRFTLSANVG DLKLRRMPEV PGLQSAPSCW
TTMCQDRVAH ILLAVGPDLY LLDHAACSAV TPPGLAPGVS SFLQMAVSFT YRHLALFTDT
GYIWMGTASL KEKLCEFNCN IRAPPKQMVW CSRPRSKERA VVVAWERRLM VVGDAPEGIQ
FVLDEDSYLV PELDGVRIFS RSTHEFLHEV PVASEEIFKI ASMAPGALLL EAQKEYEKES
QKADEYLREI QELGQLPQAV QQCIEAAGHE HWPDMQKSLL RAASFGKCFL DRFPPDSFVR
MCQDLRVLNA IRDYHIGIPL TYSQYKQLTI QVLLDRLVLR RLYPLAIQIC EYLRLPEVQG
VSRILAHWAC YKVQQKDVSD EDVARAINQK LGDTPGVSYS DIAARAYGCG RTELAIKLLE
YEPRSGEQVP LLLKMKRSKL ALSKAIESGD TDLVFTVLLH LKNELNRGDF FMTLRNQPMA
LSLYRQFCKH QELETLKDLY NQDDNHQELG SFHIRASYAA EERIEGRVAA LQTAADAFYK
AKNEFAAKAT EDQMRLLRLQ RRLEDELGGR FLDLSLHDTV TTLILSGQNK RAEQLARDFR
VPDKRLWWLK LTALADLEDW EELEKFSKSK KSPIGYLPFV EICMKQHNKY EAKKYASRVG
LEQKVKALLL VGDVAQAADV AIEHRNEAEM TLVLSHCTGA TDGAMADKIQ RARAQAQKK
//
