ID A0A2Y9SD80_PHYMC Unreviewed; 1301 AA.
AC A0A2Y9SD80;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Limbin {ECO:0000313|RefSeq:XP_023975312.1};
GN Name=EVC2 {ECO:0000313|RefSeq:XP_023975312.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023975312.1};
RN [1] {ECO:0000313|RefSeq:XP_023975312.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023975312.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_023975312.1; XM_024119544.2.
DR STRING; 9755.ENSPCTP00005028172; -.
DR KEGG; pcad:102980191; -.
DR InParanoid; A0A2Y9SD80; -.
DR OrthoDB; 4261679at2759; -.
DR Proteomes; UP000248484; Chromosome 7.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1301
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015975134"
FT TRANSMEM 288..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 28..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 454..481
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 705..788
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1301 AA; 147116 MW; 4B884DE9D8D77EF6 CRC64;
MGSAGARGRA TWVLAGGLLA AALALPAGSG DRGRPPADPG HLRRPLGAQP PLDPCSAPGV
GPEQTAKDLP HGIWPSVESS HFLTAVEAPF GVKFNKKTEV LNPPPTSAAS SGPWLHSVFA
FIPSWPKKTL FKRESAVTHR LYGDISRDIQ GTSENGVIFQ KCAVVSVQSQ WPTAHVRLFV
NNTRTPTAAN LSDLLLLDNI TGLTVRESAG NQTSRGFQAF RKKFLQVGDS FSVSYTASLE
ARDVGSGEVL LLPAQLSFQS SSQNRAQLKA LFTITTEEKI TVLPNHGLHA AGFFVAFILS
LVLTWAVLFF MVRYQCLKGS MLTRHQVQHH DSKLERSQFT SADGVNEDLA LNDQMIDILS
SEDPGSMLQA LEELEIATLN RADSDLEACR TQISKDIIAL LLKNLTSSGH LSPQVERRMG
AVFKKQFLLL EKEIQDEYDR KMVALTAECD LETRKKTESQ YQREMAAMEE AEEVLKRVSE
RSAIECSSLL RTLHGLEQEH LRRSLALQQE EDFAKAHRQL AIFQRNELHN IFFTQIKSAI
FKGELKPEAA KMLLQDYSKI QENVEELMDF FQASKRYHLS KRFGHREYLV QNIQSSETRV
QGLLSTASAQ LTLLIQKHER AGYLDEDQMR VLLERAQTEV FSIKQKLDND LKQEKKKLHQ
KLIIKRRREM LQKHKEQRRE QLSVAEAFGA AEDARQYVGQ WRSLVAEHSA TLEELQERLD
QAALDELRAL TLSLCEKATE QLRRLQNSVM TQELLKRGVP WLFLQQILEE HSRDLAARAE
RLEGEERDRG QEGIQSVRQR LKDDALEAST EEQAELRHWE HLIFMKLWSS AFSLSEEELL
GMRQEVHGCF TQMDRSLALP KIRARVLLQQ FQTAWREAEF LKLDQALAAP ELQPQSKARK
PRSKSKSKTD LLKKCTEDKI QLFEEQAPED LVEKVRGELL RERVQQLEAQ EGRFAESLVS
LQFQKAARMA KTLWAYTALL TIQDLLLEEL SASETLTKSA CTQILESHSP ELQELERELE
DQLAHQEAAQ LQRALEGRQQ WAGEGPGLLH EPEEEMDSER QVSAVLRRAL SKGQKLLEHH
QQSLREEQEN SVMLEDLLEN METDTFVTLY GQELRLASYL SKLAMLPGGA LRWLLSVAVP
AALQPELLSV LDPVGQRHQD HTAESDGGGV QADLGRRGKH QGWWQAFENK LRGELISRGL
EKMLWAHKRK ESILKKTCPP LRERVIFSGK GSWPHLSLES VGELAPVPIV GAETIDLLNT
GEKLFIFRNP KEPEISLHLP PRKKKKNFLN AKKATWALGM N
//