ID   A0A2Y9SE80_PHYMC        Unreviewed;       502 AA.
AC   A0A2Y9SE80;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=THUMP domain-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_023974600.1};
GN   Name=THUMPD2 {ECO:0000313|RefSeq:XP_023974600.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023974600.1};
RN   [1] {ECO:0000313|RefSeq:XP_023974600.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023974600.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000256|ARBA:ARBA00008361}.
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DR   RefSeq; XP_023974600.1; XM_024118832.1.
DR   AlphaFoldDB; A0A2Y9SE80; -.
DR   STRING; 9755.ENSPCTP00005010533; -.
DR   Ensembl; ENSPCTT00005011662; ENSPCTP00005010533; ENSPCTG00005007510.
DR   InParanoid; A0A2Y9SE80; -.
DR   OrthoDB; 5406466at2759; -.
DR   Proteomes; UP000248484; Chromosome 12.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd11715; THUMP_AdoMetMT; 1.
DR   Gene3D; 3.30.2130.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR004114; THUMP_dom.
DR   PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR14911:SF1; THUMP DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF02926; THUMP; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   SMART; SM00981; THUMP; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF143437; THUMP domain-like; 1.
DR   PROSITE; PS51165; THUMP; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          141..265
FT                   /note="THUMP"
FT                   /evidence="ECO:0000259|PROSITE:PS51165"
FT   REGION          418..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..437
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   502 AA;  55389 MW;  B34D21A6BC4ED45C CRC64;
     MAAVPGGRRS GLAAGARFFC TAGRGLEPFL MREVRSRLAA TQVEYISGKV FFTTCSDLNM
     LKKLKSAERL FLLIKKQLPF NVSSVSKGKI FNEMQRLTND DPESWLNAIS IWKNLLELDA
     KKVKLSQKNA NPLKRKVGEN DIIAKKLKTE RMQEIQEKKE CQLEKQIEEE TLEQGNFTTK
     RDKSQEELQN GGAEAVDTHN QNDLTFRVSC RCSGAIAKTF TAQEVGRVIG IALMKQFGWK
     ADLRNPNLEI FIHLSDIYSV VGIPVFRVPL ASRAYIKTAG LRSTVAWAMA SLAEIKAGAV
     VLDPMCGLGT ILLEAAKEWP DVYYVGADVS DSQLLGACDN LKAAGLKDKI ELLKVSVIEL
     PLPSESVDII ISDIPFGKKF KLGKDIKHII QEMERVLRVG GTIVLLLSED HQRRLKGCEE
     SSVPLNSKGS RTDKPGSTEC LNPEGKAAIS EPVSSSFAAS NQECLDRMPP LGSLVPVECY
     RVSLGKTDAL IYKYKKSHSP GQ
//