ID A0A2Y9SFB6_PHYMC Unreviewed; 1907 AA.
AC A0A2Y9SFB6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Protocadherin-15 isoform X6 {ECO:0000313|RefSeq:XP_023977063.1};
GN Name=PCDH15 {ECO:0000313|RefSeq:XP_023977063.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023977063.1};
RN [1] {ECO:0000313|RefSeq:XP_023977063.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023977063.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023977063.1; XM_024121295.1.
DR Ensembl; ENSPCTT00005027791; ENSPCTP00005025240; ENSPCTG00005011144.
DR Proteomes; UP000248484; Chromosome 20.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 9.
DR Gene3D; 2.60.40.3430; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 10.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR041149; EC_dom.
DR InterPro; IPR030718; EC_dom_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF431; CADHERIN-RELATED FAMILY MEMBER 5-LIKE ISOFORM X1; 1.
DR Pfam; PF00028; Cadherin; 8.
DR Pfam; PF18432; ECD; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 11.
DR SUPFAM; SSF49313; Cadherin-like; 10.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 10.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1907
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016099776"
FT TRANSMEM 1354..1377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 126..243
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 256..373
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 374..487
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 488..594
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 595..695
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 697..797
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 798..904
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 905..1013
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1015..1122
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1123..1237
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 1399..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1571..1613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1735..1789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1571..1604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1735..1782
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1907 AA; 211696 MW; DF345CFD2FF551B3 CRC64;
MFQQFYLWKW LASGIIFCCF FTVCLGQHDD GTILVDNMLI KGTAGGPEPT IELSLKDNVD
YWVLLDPVKQ MLFLNSTGRV LDRDPPMNIH SIVVQVQCIN KKVGTVIYHE VRIVVRDRND
NSPTFKHESY YATVNELTPV GTTVFTGFSG DNGATDIDDG PNGQIEYVIQ YNPDDPTSND
TFEIPLMLTG NVVLRKRLNY EDKTRYFVII QANDRAQNLN ERRTTTTTLT VDVLDGDDLG
PMFLPCVLVP NTRDCRPLTY QAAIPELRTP EELNPIIVTP PIQAIDQDRN IQPPSDRPGI
LYSILVGTPE DYPRFFHMHP RTAELSLLEP VNRDFHQKFD LVIKAEQDNG HPLPAFASLH
IEILDENNQS PYFTMPSYQG YILESAPVGA TISDSVNLTT PLRIVALDKD IEDTKDPELH
LFLNDYTSVF TVTQTGITRY LTLLQPVDRE EQQTYTFSIT AFDGVQESEP VVVNIRVMDA
NDNTPTFPEI SYDVYVYTDM NPGDSVIQLT AVDADEGSNG EITYEILVGA QGDFIINKTT
GLITIAPGVE LIVGRTYALT IQAADNAPPA ERRHSICTVY IEVLPPNNQS PPRFPQLMYS
LEISEAMRVG AVLLNLQATD REGDPITYAI ENGDPQRVFN LSETTGILIL GKALDRESTD
RYILIVTASD GRPDGTSTAT VNVVVTDVND NAPVFDPYLP RNLSVVEEEA NAFVGQVRAT
DPDAGINGQV HYSLGNFNNL FRITSNGSIY TAVKLNREVR DYYELVVVAT DGAVHPRHST
LTLAIRVLDI DDNSPVFTNS TYTVVVEENL PAGTTFLQIE AKDVDLGANV SYRIRSPEVK
HFFALHPFTG ELSLLRSLDY EAFPDQEASI TFLVEAFDIY GTMPPGIATV TVIVKDMNDY
PPVFSKRIYK GMVAPDAVKG TPITTVYAED ADPPGLPASR VRYRVDDVQF PYPASIFDVE
EDSGRVITRV NLNEEPTTIF KLVVVAFDDG EPVMSSSATV KILVLHPGEI PRFTQEEYRP
PPVSELATRG TMVGVISAAA INQSIVYSIV AGNEEDKFGI NNITGVIYVN APLDYETRTS
YVLRVQADSL EVVLANLRVP SKSNTAKVYI EIQDENDHPP VFQKKFYIGG VSEDARMFDS
VLRVKATDKD TGNYSAMAYR LIIPPIKEEK EGFVVETYTG LIKTAMLFHN MRRSYFKFQV
IATDDYGKGL SGKADVLVSV VNQLDMQVIV SNVPPTLVER KIEDLTEILD RYVQEQIPGA
KVVVESIGAR RHGDAFSLED YTKCDLTVYA IDPQTNRAID RNELFKFLDG KLLDINKDFQ
PYYGEGGRIL QIRTPEAVTS IKKRGESLGY TEGALLALAF IIILCCIPAV LVVLVSYRQR
QAECTKTARI QSALPAAKPA APAPAPVAMP PPAPPAPPPP GAHLYEELGD STMHNLFLLY
HFQQSRENKS VSEDRKHQHF SNTVEAHKQT HVDGSVKNSW PKSAREFTLM SDDDDLYTHS
TIYKEYTDQR PTNSDFLLRT DFVESLLPKM QAKNEFLRGP REKIQRMWNR PICLPRRPMW
ELPNRSETIA LKQRQSNRQE AENESTGTNP NKRGNSSPLL TAEDTNVTEK EEIRQSESLI
IQGTEQLQSL SSDSSLSSPW SHSSFSTLPT VSRPVELKSE PNVVVSPADC SLELSPSMPC
ILNSAPLNRE TPTCMMTFET KRDIFENLPH PLKISPPPPP VPLILSPFAL SSLPPSPPSN
SLLPPPPLLP LSVPPPPPST SPPPSLSSLP PPSPPLPSSL PPSTSVPSTK CVLTPAIKHT
VSVTPAKEMK STVIQLSTST TVCNANPQRE PKGILKHIKN LAELEKSVAN MYSQIEKNNP
PAHLLKLQMS CPSETTNMEM TSEQNQENLH NIVEGIEKQT HSQSTSL
//
