ID A0A2Y9SFS5_PHYMC Unreviewed; 1407 AA.
AC A0A2Y9SFS5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Regulator of G-protein signaling 12 isoform X3 {ECO:0000313|RefSeq:XP_023975145.2};
GN Name=RGS12 {ECO:0000313|RefSeq:XP_023975145.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023975145.2};
RN [1] {ECO:0000313|RefSeq:XP_023975145.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023975145.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_023975145.2; XM_024119377.2.
DR STRING; 9755.ENSPCTP00005024576; -.
DR Ensembl; ENSPCTT00005027077; ENSPCTP00005024576; ENSPCTG00005017623.
DR KEGG; pcad:102987394; -.
DR Proteomes; UP000248484; Chromosome 7.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13162; PTB_RGS12; 1.
DR CDD; cd17136; RBD1_RGS12; 1.
DR CDD; cd08742; RGS_RGS12; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR037880; RGS12_RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF1; REGULATOR OF G-PROTEIN SIGNALING 12; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF16613; RGS12_us1; 1.
DR Pfam; PF16611; RGS12_us2; 1.
DR Pfam; PF16612; RGS12_usC; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 22..95
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 714..831
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 961..1031
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 1033..1103
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 177..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1327
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1407 AA; 150963 MW; ECC1AFD386B6EFFC CRC64;
MYRAGDLGER PLLGTAPPRM RSVEVARGRA GYGFALSGQA PCVLSCVMRG SPADFVGLRA
GDQVLAVNEI SVKKASHEDV VKLIGKCSGV LHMVIGEGIG HLESCSSDEE VGFYEGKGWL
KPKLDSKALG INRAERVVEE MQSGGIFNMI FESPGPRASG SEPLKLKQRS LSESATGRFD
LGHESVNNPN TSLPPKEEIP KGVNDDSVFS VGLETHEDFG VDASILNVAM VVGYLGSIEL
PSTSCSLESD SVQAIRGCLR RLRAEQKIHS LVTMQIMHDC VQLCTDKAAV LARYPAERLA
FSAVCPDDRR FFGLVTMQAA DDGSLAQEEE GVLRTSCHVF MVDPDLFSHK IHQGIARRFG
FECTADPDTS GCLEFPASSL PVLQFISVLY RDMGELIEGV RARAFADGDA DAHHNASTSS
NSDSGIGNFT HEDRSSRVLV VDLGASSSRH GPSGSAWEGV VARGSQPWGG PWNGAFGHDP
EGAPFEAAPQ ADRCRDLGKH LGPTAHVEGP PASLRCSVPP SKRGAAGAGG GFGQRWLPVH
VLQEWQCGHT SDQESYTDST DGWSSVNCGT LPPPMSKIPA DRYRVEGSPA QPPPSAQKRD
WARKALGMQN IFGPHRNVRK TKEDKKGSKF GRGIGLLPPA QRTSARRSFG RSRRLSITRS
LDDLESATVS DGELNGADLK DCVSNHSLSS NASLPSVQSC RRLRERRVAS WAVSFERLLQ
DPLGVHYFSD FLRKEFSEEN ILFWQACECF NRVPAHDKKE LSYRAREIFS KFLSSKATTP
VNIDSQAQLA DDILSAPHPD MFKEQQLQIF NLMKFDSYTR FLKSPLYQEC ILAEVEGRPL
PDAQQVPSSP TSKHSVSSDH SNASTPKKLS GKSKSGRSLN EELGDEDSEK KRKGAFFSWS
RTRSTGRSQK KKDQGDRPND PLHTNGGLGR RESQGSMSSA GSLDLPEACR TLAPEKDKAA
KHCSIQLPDG TACVVLVRPG LSIKEVLAGL CERHGINGAA VDLFLVGGDK PLVLHQDSSI
LESRDLRLEK RTLFRLDLVP INRSVGLKAK PSKPVTEVLR PVAAKYGLRL SELVARLSGE
KEPLDLGAPI SSLDGQRVIL EEKDPSRGKA STDKQKSAPV KQSAAVNASS RKHSATGEER
TLGKSNSIKI KGENGKNARD PRLSKREESI AKIGKKKYQK INLDEAEEFF ELISKAQSSR
ADDQRGLLRK EDLVLPEFLR LPPSPPGLAL SPSAAPRAFC TRPATGHGEE SAPRPRGSPA
TSPGSADSPP LCAPGTPSPP AQAVEAGGVQ TVEGEHVADL TLTGEGHISS PNSTFLPPPP
TLPGSAAPPR PGGGARGSRG LLPGSTIVHV DRVAGSAPGP GSSVPGVWTG PRRSRAGGTP
TSDRPGLSPV PGGPAKPKAG PHHATFV
//
