ID A0A2Y9SI38_PHYMC Unreviewed; 1682 AA.
AC A0A2Y9SI38;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN7A {ECO:0000313|RefSeq:XP_023978093.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023978093.2};
RN [1] {ECO:0000313|RefSeq:XP_023978093.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023978093.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR RefSeq; XP_023978093.2; XM_024122325.3.
DR STRING; 9755.ENSPCTP00005004089; -.
DR KEGG; pcad:102994014; -.
DR InParanoid; A0A2Y9SI38; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000248484; Chromosome 2.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF14; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132,
KW ECO:0000313|RefSeq:XP_023978093.2};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 121..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 372..398
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 509..526
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 546..567
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 579..598
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 711..731
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 974..992
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1004..1021
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1063..1085
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1171..1198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1256..1274
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1286..1308
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1320..1344
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1383..1409
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1421..1440
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1477..1503
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 120..407
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 508..734
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 747..931
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 938..1204
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1255..1504
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 804..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..819
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..867
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1682 AA; 193564 MW; B4EBCD257F6B9A12 CRC64;
MVASAKLEMA SPEPKRLVPF TRESLEVMEQ HNAKQHSEEH KEDLKPNTDL EVGKELPFVY
GNLPRAMVSE PLEDVDPYYK NKMTFIVVNK KRTIFRFSAT WCTLSPFNSV RRTTIKILVH
PFFRLLILIS VLIDCIFMSM TDLPKWGPAL QNTLLGIYTF EILVKFIARG IWAGSFYFFG
DPWNWLDFSV TLFEHISRYS PQNFISIFRI TRNLRILKII PLNQGLKSFG GILIHCLKKL
TGVIILTLFF LSIFSLIGMG LFMGNLKHKC LRWPQANETE TLHNRTGNPY YIRETENFYY
LEGERYALLC GNRTDAGQCP EGYVCVKAGV NPDYGYTNFD SFGWTLLALF RLMMQDYPEA
LYHQILYASG KVYMIFFVVI SFWFAFYMAS LFLGILAISC EEEKQRAAEK AKKIEPELQQ
ALTELQEGNK AAETKTTEIE MKKRSSTSMI TSLDMLDDAT IRHKEELRKS RKRCPFCWYR
FAKTFLIWNC SPCWLKLKEF VHMIIMDPFT DLFLTICIIL NVHFLALEHY PMSLETNNIL
NIENQVFIGI FTAEMIFKII AMHPYGYFQV GWNIYDSLIV FHGLVELYVT HFHGLAVFRS
FRVLRIFKLG RYWPTFKILM LTLGNSIMAL KDLVLLLFTF IFFSAVLGLK LFGSNYKIYV
CNIDEDCQLP RWHMHDFLHS FLNVFRILCG EWIETLWDCF KVAGQFSCIP FYMMVILIGN
LLILYLFLAL VNSFSSCKPA TTEENDEAKN LQRAMARIKK GINYVLSKIL CKNQNVLEET
MDNVSDIYVK ENISDHTLSE LSNTQDFLKD KEKSSGTEKN TMTEKGSQSL IPSPSVSETV
PIASEESDIE NLDNKEIQSK SGDGSSKEKV KQSSSSECST VDIAISEEEE MVYERGKPRR
LKNGYGRRSS SAQISRDSKK GKIGQNIRKT CCKIVENSCF KCFIGLVTLL STGALAFEDI
YIDQRKTIKI LLEYADMIFT YIFILEMLLK WMAYGFKAYF TNGWYQLDFM VVIVFCLSLI
GKSREELKPL ISIKFLRALR VLSQFERMKV VVRALVKTTL PTLNVLLVCL MIWLAFSIIG
VHLFAGTFYE CIDPTSGERF PISEVMNRSQ CENLVFNESM PWENAKLNFD NVGISFLSLL
QIATFNGWIT IMNSAVDSIG VNMQPNFEDN IYMYCYFIDF IIIGLFLPLS MLIGAIIANF
NKHKVKLGGS NIFITVKQKK QYHALKKLMC EVCQKPVLRP GNKFQGFVFD LVTNQVFNVI
IMVLIFFQAI TIMIQSDEQN PKIGIAVYWI NSVFVTLYTG ECVLKLIVFH YDYFTNGWNL
FDFMVVVFSI TGLFLPLMVG YYLVPPSLVQ LILLSRIIHI LRPEKGPKVF HDLLLPLMLS
LPALLNISLL IFLIMFVYAI FGMYNFAYVK KEAGINDVSN FETFGSSMLC LFQVTIFAGW
DGMLNAIFNS KWSDCDPDKI NPGTQVRGDC GNPFVGIVYF VSYILISWLI IVNMYIVVVM
EFLNIASKKK AKTLSEDDFR KFFQVWKRFD PDRTQYIDSS KLSDFAAALH PPLFMAKPNK
AQIVAMDLPM AVGDRIHCLD ILLALTKRVM SKDVSMEKVL SEMESGFMLA NPFKITYEPI
TTTLKRKQEV VSATIIQRAY KSYRLRQNDK KTSDIHMIDG DVEVQAIKED SYFDKTEGKS
TI
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