ID A0A2Y9SI58_PHYMC Unreviewed; 667 AA.
AC A0A2Y9SI58;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Kalirin isoform X8 {ECO:0000313|RefSeq:XP_023976010.1};
GN Name=KALRN {ECO:0000313|RefSeq:XP_023976010.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023976010.1};
RN [1] {ECO:0000313|RefSeq:XP_023976010.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023976010.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023976010.1; XM_024120242.2.
DR AlphaFoldDB; A0A2Y9SI58; -.
DR Proteomes; UP000248484; Chromosome 1.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11853; SH3_Kalirin_2; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047053; Kalirin_TRIO_SH3_2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22826:SF49; KALIRIN; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16609; SH3-RhoG_link; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 198..373
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 385..495
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 589..654
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 35..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 74960 MW; E26346E99BD6C0A8 CRC64;
MKGGDRAYTR GPSLGWLLAK CCCCLPCRDA YSHSSENGGK SESVANLQAQ PSLNSIHSSP
GPKRSTNTLK KWLTSPVRRL NSGKADGNIK KQKKVRDGRK SFDLGSPKPG DETTPQGDSA
DESKKGWGED EPDEESHTPL PPPMKIFDND PTQDEMSLEG GSYRGSLKDP TGCLNEGMTP
PTPPRNLEEE QKAKALRGRM FVLNELVQTE KDYVKDLGIV VEGFMKRIEE KGVPEDMRGK
DKIVFGNIHQ IYDWHKDVFL GELEKCIQEQ DRLAQLFIKY ERKLHIYVWY CQNKPRSEYI
VAEYDAYFEE VKQEINQRLT LSDFLIKPIQ RITKYQLLLK DFLRYSEKAG LECSDIEKAV
ELMCLVPKRC NDMMNLGRLQ GFEGTLTAQG KLLQQDTFYV IELDAGMQSR TKERRVFLFE
QIVIFSELLR KGSLTPGYMF KRSIKMNYLV LEENVDNDPC KFALMNRETS ERVILQAANS
DIQQAWVQDI NQVLETQRDF LNALQSPIEY QRKERNTAMM RSQPARVPQA SPRPYSSIPV
GSEKPPKGSS CNPPLPPLKI STSNGSSGFD YHQAGDKFEA TKSDLGGCNG VSSMAVIKDY
YALKENEICV SQGEVVQVLA INQQNMCLVY QPASDHSPAA EGWVPGNILA PLTKATAAAE
NSDGSIK
//