ID A0A2Y9SIK5_PHYMC Unreviewed; 1676 AA.
AC A0A2Y9SIK5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=E3 ubiquitin-protein ligase SHPRH isoform X2 {ECO:0000313|RefSeq:XP_023978283.1};
GN Name=SHPRH {ECO:0000313|RefSeq:XP_023978283.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023978283.1};
RN [1] {ECO:0000313|RefSeq:XP_023978283.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023978283.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023978283.1; XM_024122515.3.
DR Proteomes; UP000248484; Chromosome 10.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd18070; DEXQc_SHPRH; 1.
DR CDD; cd00073; H15; 1.
DR CDD; cd15547; PHD_SHPRH; 1.
DR CDD; cd16569; RING-HC_SHPRH-like; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048686; SHPRH_helical_1st.
DR InterPro; IPR048695; SHPRH_helical_2nd.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR45865:SF1; E3 UBIQUITIN-PROTEIN LIGASE SHPRH; 1.
DR PANTHER; PTHR45865; E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00538; Linker_histone; 1.
DR Pfam; PF21325; SHPRH_helical-1st; 1.
DR Pfam; PF21324; SHPRH_helical-2nd; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00526; H15; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51504; H15; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 439..513
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT DOMAIN 1433..1480
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 1515..1669
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1676 AA; 192822 MW; FDE9FAEB9D4CBA95 CRC64;
MSSRRKRAPP VRVDEEKQQQ LRWNMHEDRR NEPLTLTDDE QSFPGLDSSS AHCVILDDSL
KEEVAHKDKK RCSEVVSVSK SVEEETSGIF SPLSLKLNIV ISPYHFDNSW KAFLGELTLR
LLPEQSLIEN FSERSFTLMR SESSYQFVIY VHSECEDVEK KERGLNEPIS ICDKGIQVES
SFSGEMLEDL GWLQKKKRIK LYQKPEGNHI IKVGIYLLEG GLAKLDFLSD ANSRMKKFNQ
LMKRVMEKLY NFIIPDVLEE DEEDSESEPE GQDIDDLYHF VKRTHQQETP SNQVDVQHPA
LTPVLRPYQR EAVSWMLQQE HFKSTPASEN ALHFLWREIV TSEGLKLYYN PYTGCIIREY
PNAGPQLLGG ILADEMGLGK TVEVLALILT HTRQDVKQDA LTLPEGKVVN YFIPSHYSGG
NVKNTETQNM EFEPKEKVQC PPTRVMILTA VKEMNGKKGV SILSIYKYVS SIYRYDVQRN
RSLLKRMLKC LIFEGLVKQI KGHGFSGTFT LGKNYKEEDI HDKTKKQAVG SPRKIQKESR
KPGSKDTDSE YLPSNTSDDD DDPYYYYYKA RRNRSKLRKK PVPSTKKEKS QLNINLNSQD
HCPATGDSAV TDVTTSESTC VFEVKQKHAA KDQAESLNPV GHDMPHSNIT GPYKSSDYHF
ECICGEVDQV DRKPRVQCLK CHLWQHAKCV NYEEKNLKIK PFYCPHCLVA MEPVSTRATL
IISPSSICHQ WVDEINRHVR SSSLRVLVYQ GVKKDGFLQP HFLAEQDIVI ITYDVLRSEL
NYVDIPHSNS EDGRRLRNQK RYMAIPSPLV AVEWWRICLD EAQMVECPTV KAAEMAQRLS
GINRWCISGT PVQRGLEDLF GLVVFLGIEP YCVKHWWVRL LYRPYCKKNP QLLYSFIAKI
LWRSAKKDVI DQIQIPPQTE EIHWLHFSPV ERHFYHRQHE VCCQDAVVKL RKISDWALKL
SSLDRRTVTS ILYPLLRLRQ ACCHPQAVRG EFLPLQKSTM TMEELLTSLQ KKCGTECEEA
HRQLVCALNG LAGIHIIKGE YALAAELYRE VLRSSEEHKG KLKTDSLQRL HATHNLMELL
IAKHPGIPPT LRDGRLEEEA KQLREHYMSK CNTEVAEAQQ ALLPVQQTIR DLQRKIYSNS
PWWLNVIHRA IEFGIEEELV QRVRNEITSN YKQQTGKLSM SEKFHDCRGL QFLLTTHMED
LSKFQRQVRD AVKNLEGPPS RHVIESATIC HLRPTRLPLN CCVFCKADEL FTEYESKLFS
HTVKGQTAIF EEMIEDEEGL VDDRIPTTNR GLWAISETER SMKALLSFAK SHRFDVEFID
EGSTSMDLFE AWKKEYKLLH EYWMALRNRV SAVDELAMAT ERLRVRDPRE PKPSPPVPHI
IEPHEVEQNR IKLLNDKAVS TSQLQKKLGQ LLYLTNLEKS QDKTSGGINP EPCPICARQL
GKQWAVLTCG HCFCNECISI IIEQYSVGSH KSSIKCAICR QTTSHKEISY VFTSEKASQE
EDIPVKGSHS TKVEAVVRTL MRIQLRDPGA KALVFSTWQD VLDIISKALT DNNMEFAQIS
RVKTFQENLS AFKHDPQINI LLLPLHTGSN GLTIIEATHV LLVEPILNPA HELQAIGRVH
RIGQTKPTIV HRFLIKATIE ERMQAMLKTA ERSCREKWRL CPEMTRQQRI PDIEKQ
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