ID A0A2Y9SJA5_PHYMC Unreviewed; 1027 AA.
AC A0A2Y9SJA5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=PDZ domain-containing RING finger protein 4 isoform X1 {ECO:0000313|RefSeq:XP_023978696.1};
GN Name=PDZRN4 {ECO:0000313|RefSeq:XP_023978696.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023978696.1};
RN [1] {ECO:0000313|RefSeq:XP_023978696.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023978696.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023978696.1; XM_024122928.2.
DR AlphaFoldDB; A0A2Y9SJA5; -.
DR STRING; 9755.ENSPCTP00005024864; -.
DR Ensembl; ENSPCTT00005027390; ENSPCTP00005024864; ENSPCTG00005017632.
DR KEGG; pcad:102974663; -.
DR InParanoid; A0A2Y9SJA5; -.
DR OrthoDB; 2879659at2759; -.
DR Proteomes; UP000248484; Chromosome 6.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd16719; RING-HC_LNX4; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR15545; PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4; 1.
DR PANTHER; PTHR15545:SF6; PDZ DOMAIN-CONTAINING RING FINGER PROTEIN 4; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 18..54
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 217..307
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 395..478
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 127..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 652..679
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 511..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..576
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1027 AA; 116065 MW; 799336F11CB146AA CRC64;
MGFALERFAE AVDPDFQCRL CGQVLEEPLC TPCGHVFCAR CLMPWAARRR RCPLQCQPLA
PGDLYRVLPL RSLVQKLRTQ CDYRARGCGH SVGLRELAAH VERCDFGPAR RRRRGCVSGP
GGGDASARGG CGSAPGVRRG GTPGVRGGSG RAPGPQVLAW RRREKALLAQ LWALQGEVQL
TARRYQEKFT QYMAHVRKFA RDPGGGRGRD GEHKPFTIVL ERENDTLGFN IIGGRPNQDN
QEEAPMEGIY VSKILENGPA DRADGLEIHD KIIEVNGKDL SKATHEEAVE AFRNAKEPIV
VQVLRRTPLS KPAYGTAPEV RLVNASTQTD ITFEHIMALA KLRPPTPPVP DICPFLLSDS
CHSLHPMEHE FYEDNEYLSS LPADADRTED FEYEEVELCR VNSQEKLGLT VCYRTDDEED
TGIYVSEVDP NSIAAKDGRI REGDRILQIN GEDVQDREAA VALLSSDECR RIVLLVARPE
SQLEEGWLED ERNEYLEELN LSMLEEQHNE AMQRTAGEVE QPKKQEEEEG TTDTATSSSN
NHEKDSGVGR TDESLRNDES SEQENAAEHP NDTSLKSKRE LGQSQDTLGS VELQCNESFV
SGEYIDSDCI GNQDEECERF RQLLELKCKI RKHGEYDLYY SSSTIECNQG GREGVEHELQ
LLNEELRNIE LECQNIMQAH RLRKVTDQYG DIWALHDGGF RNYNTSIDTQ RGKLDDILEH
PEKSDKDSSS AYNTAESCRS TPLTVDRSPD SSLPRMINLT NKKNLRSTMA ANQSSSGQSS
KESTKAKTTE QGCGVEGKEQ TSESSKLSDP EKTSGEHIPY LSPYHSSSYR YANIPTHARH
YQSYMQLIQQ KSAVEYAQSQ LSLVSVCKES QKCSEPKMEW KVKIRSDGTR YITKRPVRDR
ILKERALKIK EERSGMTTDD DTMSEMKMGR YWSKEERKQH LVRAKEQRRR REFMMRSRLE
CLKESPQSGS EGKKEVNIIE LSHKKMMKKR NKKILDNWMT IQELMTHGAK SPDGTRVPNA
FLSVTTV
//
