ID A0A2Y9SJG2_PHYMC Unreviewed; 1997 AA.
AC A0A2Y9SJG2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRB {ECO:0000313|RefSeq:XP_023978558.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023978558.1};
RN [1] {ECO:0000313|RefSeq:XP_023978558.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023978558.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR RefSeq; XP_023978558.1; XM_024122790.3.
DR Ensembl; ENSPCTT00005010436; ENSPCTP00005009477; ENSPCTG00005006402.
DR KEGG; pcad:102986627; -.
DR Proteomes; UP000248484; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 14.
DR CDD; cd14617; R-PTPc-B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF2; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA; 1.
DR Pfam; PF00041; fn3; 15.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 17.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 16.
DR PROSITE; PS50853; FN3; 10.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_023978558.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1997
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015932557"
FT TRANSMEM 1616..1642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..205
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 291..379
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 469..558
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 642..733
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 734..820
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 821..908
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 909..1005
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1087..1175
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1260..1356
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1357..1448
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1703..1963
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1878..1954
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1997 AA; 223548 MW; 64E48AE9B18AB4F7 CRC64;
MRSHGAGLAL WTALSLLQTG LGEPVRCNFT LTESRVSSRS VSLQWRTLAS PCNFSLICSS
DTSGVACCHP VRIDNTTYGC NPKDLQAGTI YNFTIMSLDG EEKTVVLQTD PLPPARFEVN
KEKSTSTSLH VWWTPSSGKV TWYEVQLLDD NQKTQGAQIQ ERTSRNEYTF FNLTAGSKYK
IAITAVSGDK RSSTIYANGS TVPSPVKDIG ISAKTNSLLI SWSRGSGNVE RYQLILMDKG
ILVHSYAVDK STTSYAFHGL IPGHLYNVTI VTEAAGLQNY RWKPARTTPM EVSNLKVTND
GTLTSLKVKW QRPSGNVDFY NITLSHQGTI KESRILAPQI TETQFKDLAP GRLYQVTISC
VSGELSAHKM AVGRTVPEKV GDLEANSNGS TRSLVVSWSP PAGDWEQYRI LLLNDSLVLL
NTTVGKEETH YVIGDVGLIP GRQYEVEVTV ESGNLKNSKR CHGRTVPLAV LQLRVKHANE
TSLGVMWQTP AAEWEKYIIS LIDRDLLLIH KLLPKDAKEF TFTDLVPGRK YIATVSSISG
DLKNSSSTKG RTVPAQVTGL HVANQGTTSS LFTNWTQALG DIDFYQVLLI HENVVIKNES
VSSETSRYSF HSLKSGSLYS MVVTTVSGGI SSRQVVMEGR TVPSSVSGVR VNNSGRNDYL
SISWLPAPGD VDNYVVTLSH DGRVVQSLMI AKSVSECSFS SLTPGRLYNV TITTRSGKYE
NHSFGQERTV PDKVQGVSIS NSARSDYLKV SWVHATGDFD HYEVTIKNKN NFIQTKSIPK
SENECIFVKL VPGRLYSVTV TTKSGQYEAS EQGNGRTIPE AVKDLTLRNR STEDLQVTWT
RADGDVDQYE IQLLFNDMKV FPPFHLVNTA TEYRFTSLTP GRQYKILVLT ISGDVQQSAF
IEGFTVPSVV KNIHVSPNGA TDSLTVNWTP GGGDVDSYAV SAFRQNQKVE SQTVPKLVSE
HTFHRLEAGE QYRIVITSVS GSQKNQVDAL GRTVPASVQG ITADNAYSSH SLIVSWQKAV
GVAERYDILL LSENGILLSN TSEAATTKQH KFEDLTPGKK YKIQILTVSG GLFSKEAQTE
GRTVPAAVTN LRITENATRH LSFSWTPSEG ELNWYNIFLY NPDRTLQERA QVGPQVQSFS
FQNLLQGRMY KMVIVTHSGE LSNESSIFGR TVPASVSNLK GSNRNMTDSL WFSWSPASGD
FDFYELILYN PNGTKKENWK DKELTEWRFH GLVPGRKYTL CVITHSGDLS NKVTAESRTA
PSPPSLMSFA DVANTSLAIT WKGPPDWTDY DDFELQWFPR DAVTVFNPYS NRKSEGRIVY
GLRPGRSYQF SVKTVSGDSW KTYSKPIFGS VRTKPDKIQN LHCRPQNSTA IACSWIPPDS
DFDGYSIECR KMDTQEVEFS RKLEKEKSLL NIMMLVPHKR YLVSIKVQSA GMSSEVVEDS
TITMIDRPPP PPPHIRVNKK DVLISKSSIN FTFNCSWFSD TNGAVKYFTV VVREADGSDE
LKPEQQHPLP SYLEYRHNAS IRVYQTDYFA SKCAESPDSN SKSFNIKLGA EMESLGGKCD
PNQQKFCDGP LKPRTAYRIS IRAFTQLFDE DLKEFTKPLY SDTFFSLPIT TESEPLFGVI
EGVSAGLFLI GMLVAVVALL ICRQKASHGR ERPSARLSIR RDRPLSVHLN LGQKGNRKTS
CPIKVNQFEG HFMKLQADSN YLLSKEYEDL KDVGRNQSCD IALLPENRGK NRYNNILPYD
ASRVKLSNVD DDPCSDYINA SYIPGNNFRR EYIATQGPLP GTKDDFWKMA WEQNVHNIVM
VTQCVEKGRV KCDHYWPADQ DSLYYGDLIL QMLSESVLPE WTIREFRICS EEQLDAHRLI
RHFHYTVWPD HGVPETTQSL IQFVRTVRDY INRTPGAGPT AVHCSAGVGR TGTFIALDRI
LQQLDSKDSV DIYGAVHDLR LHRVHMVQTE CQYVYLHQCV RDVLRARKLR SEQENPLFPI
YENVNPEYHR DAGYSRH
//
