ID   A0A2Y9SL30_PHYMC        Unreviewed;       836 AA.
AC   A0A2Y9SL30;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Protocadherin gamma-A8 {ECO:0000313|RefSeq:XP_023979341.1};
GN   Name=LOC102983961 {ECO:0000313|RefSeq:XP_023979341.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023979341.1};
RN   [1] {ECO:0000313|RefSeq:XP_023979341.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023979341.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_023979341.1; XM_024123573.1.
DR   AlphaFoldDB; A0A2Y9SL30; -.
DR   KEGG; pcad:102983961; -.
DR   InParanoid; A0A2Y9SL30; -.
DR   Proteomes; UP000248484; Chromosome 8.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 5.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF72; PROTOCADHERIN GAMMA-A8; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..836
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016165538"
FT   TRANSMEM        689..714
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          75..133
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          134..242
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          243..347
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          348..452
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          453..562
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          579..683
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   836 AA;  91287 MW;  FCB3973E122A5EF5 CRC64;
     MATPKNYRGR GHLVLLCALL GTLGEIGRGQ IHYSVPEESD KGSFVGNISK DLGLESHELA
     QHGVHIVSRG RTQLFALNPG SGSLVTAGRI DREELCAQSA RCLVNINILV EDKGKLWGIE
     IEITDINDNN PKFQVENLEV KINEIALPGT RYPLPEAVDP DVGLNSLQSY QLSPNHHFSL
     DVQTGDDGTI SPELVLERAL DREEEAAHHL VLVASDGGEP RRSSTVHIRV TVLDTNDNAP
     VFTQPIYRVK VPENVPPGTR LLTVSASDPD EGTNGEVAYK FWKISEKQSP LFQLNENTGE
     ISTAKSLDYE ECAFYDMEIQ AEDVGALLGR TKVLISVEDV NDNRPEVTIT SLFSPVLENT
     LPGTVIAFLN VHDRDSGKNG QVVCYTRDNL PFQLEKSIDN YYRLVIWEYL DREKISMYNI
     TVMASDLGTP PLSTEIHIAL HVADINDNPP IFPHASYSAY IPENNPRGAS IFSVTAHDPD
     SGNNAQVTYS LTKDTIMATP LSSYVSINSD TGVLYALCSF DYEQIQDLQL LVTASDSGDP
     PLSSNVSLSL FILDQNDNVP EILYPMLPTD GSMGVELAPR SAEPGYLVTK VVAVDRDSGQ
     NAWLSYHLLK ASEPGLFAVG LHTGEVRTAR ALLDRDTLKQ SLVVAVQDHG QPPLSATVTL
     TVAVASSIPE VLADLGSMRT PTNSDDSDLT LYLVVAVAVV SCIFLAFVIV LLALRLWRWH
     KSSLIQSSGV GLAGLPASGF VGMEGVQAFL KTYSHEVSLT SDLRGSHMIF PQPNYADTLI
     SQESCEKNDS LLASRDFHEC RDEAASVQVS SVLCLHLFLR GIIFFTNLSC VLKHAL
//