ID A0A2Y9SMR2_PHYMC Unreviewed; 2865 AA.
AC A0A2Y9SMR2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Adenomatous polyposis coli protein isoform X2 {ECO:0000313|RefSeq:XP_023979641.1, ECO:0000313|RefSeq:XP_023979643.1};
GN Name=APC {ECO:0000313|RefSeq:XP_023979641.1,
GN ECO:0000313|RefSeq:XP_023979643.1, ECO:0000313|RefSeq:XP_054942682.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023979643.1};
RN [1] {ECO:0000313|RefSeq:XP_023979641.1, ECO:0000313|RefSeq:XP_023979643.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023979641.1,
RC ECO:0000313|RefSeq:XP_023979643.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR RefSeq; XP_023979641.1; XM_024123873.3.
DR RefSeq; XP_023979643.1; XM_024123875.3.
DR RefSeq; XP_054942682.1; XM_055086707.1.
DR Ensembl; ENSPCTT00005000708; ENSPCTP00005000634; ENSPCTG00005000519.
DR Proteomes; UP000248484; Chromosome 8.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.10; -; 1.
DR Gene3D; 1.10.287.450; Helix hairpin bin; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009240; APC_15aa_rpt.
DR InterPro; IPR009234; APC_basic_dom.
DR InterPro; IPR026831; APC_dom.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR032038; APC_N.
DR InterPro; IPR036149; APC_N_sf.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR009232; EB1-bd.
DR InterPro; IPR009224; SAMP.
DR PANTHER; PTHR12607:SF11; ADENOMATOUS POLYPOSIS COLI PROTEIN; 1.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR Pfam; PF05972; APC_15aa; 4.
DR Pfam; PF05956; APC_basic; 1.
DR Pfam; PF16689; APC_N_CC; 1.
DR Pfam; PF05923; APC_r; 7.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF16634; APC_u13; 1.
DR Pfam; PF16635; APC_u14; 1.
DR Pfam; PF16636; APC_u15; 1.
DR Pfam; PF16630; APC_u5; 1.
DR Pfam; PF16633; APC_u9; 1.
DR Pfam; PF00514; Arm; 3.
DR Pfam; PF16629; Arm_APC_u3; 1.
DR Pfam; PF05937; EB1_binding; 1.
DR Pfam; PF05924; SAMP; 3.
DR Pfam; PF11414; Suppressor_APC; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF58050; N-terminal coiled coil domain from apc; 1.
DR SUPFAM; SSF82931; Tumor suppressor gene product Apc; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 4..55
FT /note="Adenomatous polyposis coli N-terminal dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16689"
FT REPEAT 678..720
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 2246..2597
FT /note="Adenomatous polyposis coli protein basic"
FT /evidence="ECO:0000259|Pfam:PF05956"
FT DOMAIN 2692..2865
FT /note="EB-1 binding"
FT /evidence="ECO:0000259|Pfam:PF05937"
FT REGION 239..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1076..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1328..1396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1541..1632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1684..1873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1897..1965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1988..2033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2067..2090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2169..2658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2686..2865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 6..54
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 134..168
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 244..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..875
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..965
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1328..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1377..1394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1453..1468
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1565..1583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1701..1715
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1716..1733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1770..1784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1808..1853
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1897..1916
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1917..1936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1945..1959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2000..2017
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2192..2213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2222..2247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2256..2271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2280..2448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2483..2523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2541..2555
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2579..2602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2603..2618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2639..2658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2691..2712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2719..2736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2759..2835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2845..2865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2865 AA; 314072 MW; 28A381B66BEE765E CRC64;
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDEAM
ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE GSVSSRSGEC SPVPMGSFPR
RGFVNGSREN TGYLEELEKE RSLLLADLDK EEKEKDWYYA QLQNLTKRID SLPLTENFSL
QTDMTRRQLE YEARQIRVAM EEQLGTCQDM EKRAQRRITR IQQIEKDILR IRQLLQSQAT
EAERSSQSKH EASSHEAERQ NESQGVAEIN MATSGSGQGS TARIDHETAS VLSSSSTHSA
PRRLTSHLGT KVEMVYSLLS MLGTHDKDDM SRTLLAMSSS QDSCISMRQS GCLPLLIQLL
HGNDKDSVLL GNSRGSKEAR ARASAALHNI IHSQPDDKRG RREIRVLHLL EQIRAYCETC
WEWQEAHEQG MDQDKNPMPA PVEHQICPAV CVLMKLSFDE EHRHAMNELG RKATRGISSQ
ELGQGLSGGL QAIAELLQVD CEMYGLTNDH YSITLRRYAG MALTNLTFGD VANKATLCSM
KGCMRALVAQ LKSESEDLQQ VIASVLRNLS WRADVNSKKT LREVGSVKAL MECALEVKKE
STLKSVLSAL WNLSAHCTEN KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV
SSLIATNEDH RQILRENNCL QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG
AVSMLKNLIH SKHKMIAMGS AAALRNLMAN RPAKYKDANI MSPGSSLPSL HVRKQKALEA
ELDAQHLSET FDNIDNLSPK ASHRSKQRHK QNLYGDYVFD TNRHDDNRSD NFNTGNMTVL
SPYLNTTVLP SSSSSRGSVD SSRSEKDRSL ERERGISLVN YHPATENPGT SSKRGLQIST
TAAQIAKVME EVSAIHTSQE DRSSGSTPEL HCGTDERNAL RRSSTAHTHA NSYNFTKSEN
SNRTCPVPYA KVEYKRSSND SLNSVSSSDG YGKRGQMKPS VESYSEDEES KFCSYGQYPA
DLAHKIHSAN HMDDNDGELD TPINYSLKYS DEQLNSGRQS PSQNERWARP KHIIEDEIKQ
NEQRQSRSQS TTYPVYPEST DDKHLKFQPH FGQQECVSPY RSRAANGSET NRVGSNHGIN
QNVNQSLCQE DDYEDDKPTN YSERYSEEEQ HEEEERPTNY SIKYNEEKHH VDQPIDYSLK
YTTDIPSSQK PAFSFSKNSS GQSTKTEHIS SSSENTSTPS SNAKRQNQLH PSSAQSRSGQ
AQKATSSSCK VPSINQETIQ TYCVEDTPIC FSRCSSLSSL SSAEDEIGCD QTTQEADSAN
TLQIAEIKEN SGTRSTEDSV SEVPTVSQHI RTKSSRLQAS GLSSESARHK AVEFSSGAKS
PSKSGAQTPK SPPEHYVQET PLMFSRCTSV SSLDSFESRS IASSVQSEPC SGMVSGIISP
SDLPDSPGQT MPPSRSKTPP PPPPQTAQTK QEVPKNKAPS AEKRESGPKQ AAVNAAVQRV
QVLPDADALL HFATESTPDG FSCSSSLSAL SLDEPFIQKD VELRIMPPVQ ENDNGNETEN
EQPEESNENQ GKEAEKPTDS EKDLLDDSDD DDIEILEECI ISAMPTKSSR KAKKPAQTSS
KLPPPVARKP SQLPVYKLLP SQNRLQAQKH VSFTPGDDMP RVYCVEGTPI NFSTATSLSD
LTIESPPNEL AAGEGVRAGT QSGEFEKRDT IPTEGRSTDE AQTGKASSVT IPELDDSKTE
EGDILAECIN SAMPKGKSHK PFRVKKIMDQ VQQASMSSSG TNKNQLDGKK KKPTSPVKPI
PQNTEYRTRV RKNTDSKNNL NAERNFSDNK DSKKQNLKNN SKDFNDKVPN NEDRVRGSFT
FDSPHHYTPI EGTPYCFSRN DSLSSLDFDD DDVDLSREKA ELRKGKENKE SEAKVTNHTE
LTSNQQSANK TQAVPKHPIN RGQPKPVLQK QSTFPQSSKD IPDRGAATDE KLQNFAIENT
PVCFSRNSSL SSLSDIDQEN NNNKENEPIK ETEPPDSQGE PSKPQASGYA PKSFHVEDTP
VCFSRNSSLS SLSIDSEDDL LQECISSAMP KKKKPSRLKA DNEKHSPRNM GGILVEDLTL
DLKDIQRPDS EHGLSPDSEN FDWKAIQEGA NSIVSSLHQA AAAACLSRQA SSDSDSILSL
KSGISLGSPF HLTPDQEEKP FASNKGPRIL KPGEKSTLET KKLESENKGI KGGKKVYKSL
ITGKVRSNSE VSSQMKQPLQ ANMPSLSRGR TMIHIPGVRN SSSSTSPVSK KGPPLKTPAS
KSPSEGQAAT TSPRGAKPSV KSELSPVTRQ ASQTPGSNKG PSRSGSRDST PSRPAQQPLS
RPMQSPGRNS ISPGRNGISP PNKLSQLPRT SSPSTASTKS SGSGKMSYTS PGRQMSQQNL
TKQTGFSKNV SSIPRSESAS KGLNQMSTSN GSNKKVELSR MSSTKSSGSE SDRSERPVLV
RQSTFIKEAP SPTLRRKLEE SASFESLSPS SRPDSPTRSQ AQTPILSPSL PDMSLSTHSS
VQAGGWRKLP PNLSPTIEYN DGRPVKRHDI ARSHSESPSR LPINRSGTWK REHSKHSSSL
PRVSTWRRTG SSSSILSASS ESSEKAKSED EKHVNSTSGS KQTKENQVST KGTWRKMKES
EISPTNSTSQ TTSSGAANGA ESKTLIYQMA PAVSKTEDVW VRIEDCPINN PRSGRSPTGN
TPPVIDTVTE KGNPNTKDSK DNQGKQNVSN GSAPVRTMGL ENRLNSFIQV DAPDQKGTEA
KPGQSNPVPA SEANESSIAE RTPFSSSSSS KHSSPSGTVA ARVSPFNYNP SPRKSSADST
SARPSQIPTP VNNNTKKRDS KTDNTESSGT QSPKRHSGSY LVTSV
//
