ID A0A2Y9SPV5_PHYMC Unreviewed; 446 AA.
AC A0A2Y9SPV5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=SPARC-related modular calcium-binding protein 2 isoform X2 {ECO:0000313|RefSeq:XP_023978410.1};
GN Name=SMOC2 {ECO:0000313|RefSeq:XP_023978410.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023978410.1};
RN [1] {ECO:0000313|RefSeq:XP_023978410.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023978410.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR RefSeq; XP_023978410.1; XM_024122642.3.
DR AlphaFoldDB; A0A2Y9SPV5; -.
DR KEGG; pcad:102989549; -.
DR Proteomes; UP000248484; Chromosome 10.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00191; TY; 2.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR12352; SECRETED MODULAR CALCIUM-BINDING PROTEIN; 1.
DR PANTHER; PTHR12352:SF21; SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 2; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR Pfam; PF16597; Thyroglob_assoc; 1.
DR Pfam; PF00086; Thyroglobulin_1; 2.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00211; TY; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 2.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..446
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016036259"
FT DOMAIN 35..87
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 88..154
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 214..282
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 347..382
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 148..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 125..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 134..154
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 252..259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 446 AA; 49899 MW; AEAC13F26A5D2BAD CRC64;
MLLPRLCWLP LLAGLLLPRA PAQKFSALTF LRVDQDKDKD CSLDCGGPAQ KPLCASDGRT
FLSRCEFQRA KCKDPRLEIA YRGNCKDASR CVAERKYTQE QARKELQQVF IPECKDDGTY
SQVQCHSYTG YCWCVTPNGR PISGTAVAHK TPRCPGSINE KLPQREGTGK TDDASAPALE
TQPQGDEEDI ASRYPTLWTE QVKSRQNKTN KNSVSSCDQE QQSALEEARQ PKNDNVVIPE
CAHGGLYKPV QCHPSTGYCW CVLVDTGRPI PGTSTRYEQP KCDNTARAHP TKTRDLYKGR
QLQGCPGAKK NEFLTSVLDA LSTDMVHAVS DPSSPGRLSE PDPSHTLEER VVHWYFKLLD
KNSSGDIGKK EIKPFKRFLR KKSKPKKCVK KFVEYCDVSN DKSLSLQELM GCLGATREEG
ETNTRKRHTP RGNAESTSNR QPRKQG
//
