ID A0A2Y9SST2_PHYMC Unreviewed; 1041 AA.
AC A0A2Y9SST2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LATS2 {ECO:0000313|RefSeq:XP_023981716.1,
GN ECO:0000313|RefSeq:XP_028353130.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023981716.1};
RN [1] {ECO:0000313|RefSeq:XP_023981716.1, ECO:0000313|RefSeq:XP_028353130.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023981716.1,
RC ECO:0000313|RefSeq:XP_028353130.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023981716.1; XM_024125948.3.
DR RefSeq; XP_028353130.1; XM_028497329.2.
DR STRING; 9755.ENSPCTP00005014660; -.
DR Ensembl; ENSPCTT00005016222; ENSPCTP00005014660; ENSPCTG00005010509.
DR KEGG; pcad:102991681; -.
DR OrthoDB; 5348633at2759; -.
DR Proteomes; UP000248484; Chromosome 13.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0035329; P:hippo signaling; IEA:Ensembl.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0001827; P:inner cell mass cell fate commitment; IEA:Ensembl.
DR GO; GO:0001828; P:inner cell mass cellular morphogenesis; IEA:Ensembl.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:1900181; P:negative regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR GO; GO:0046620; P:regulation of organ growth; IEA:Ensembl.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd21777; MobB_LATS2; 1.
DR CDD; cd14398; UBA_LATS2; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24356:SF149; SERINE_THREONINE-PROTEIN KINASE LATS2; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00433; Pkinase_C; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_023981716.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 98..139
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 620..925
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 926..1004
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 649
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1041 AA; 113310 MW; DF7002C9355A1F8C CRC64;
MRPKTFPATT YSGNSRQRLQ EIREGLKQPP KTPTPGPPAG PGGDAALDAK ALGGKDAARQ
QQQTRTAPKF GPYQKALREI RYSLLPFANE SGPSAAAEVN RQMLQELVDA GCDQEMAGRA
LKQTGSRSIE AALEFISKMG YLEPGKEQIV RVVKQTSPGK GLAPASVPRR PSFEGAGDPF
PPYAQVSGPA FEGPAAMEEA PRQYPDFLFA AVGPHCRPHP PKGYATAGEA TGMSIPGPGG
PAPPLQGPHY RAPLLVPGEP LGYGVQRSPS FQSKTPPEVG GYAGLAAKGP AVQVQVQPGL
AFPPPGGAAA YAPHPHPKQT HPVHAGGPRG AVFAGDSPPP GLATPSRTGL GAERFEPSAP
PAPQWPSAGL ARRDSLQKPG PSRTGSFNGH QAAAAPSPNA ITAVTAAHIL HAVKSVRVMR
PEPQTAVGPS HPAWVPPPGP ALEGLEPQDE HPAAPGGAEA RGRPPPYPRH LLRPQGRAEQ
YDVDGLCAGL QQGLRGSRAA EPPDGSPRSP RGAKGEKAGK DRKQIQTSPV PVRRGCRDEE
KRESRIKSYS PSAFKFFMEQ HVENVLKTYQ QKVARRLQLE QEMAKAGLCE AEQEQMRKIL
YQKESNYNRL KRAKMDKSMF VKVKTLGVGA FGEVCLACKV DTHALYAMKT LRKKDVLNRN
QVAHVKAERD ILAEADNEWV VKLYYSFQDK DSLYFVMDYI PGGDMMSLLI RMEVFPEHLA
RFYIAELTLA IESVHKMGFI HRDIKPDNIL IDLDGHIKLT DFGLCTGFRW THNSKYYQKG
SHTRQDSMEP SDLWDDVSNC RCGDRLKTLE QRARRQHQRC LAHSLVGTPN YIAPEVLLRK
GYTQLCDWWS VGVILFEMLV GQPPFLAPTP TETQLKVINW ESTLHIPAQV ELSPEARDLI
AKLCCSAEHR LGRNGADDLK AHPFLGAIDF SSDIRRQPAP YVPTISHPMD TSNFDPVDEE
GPWQDGSEDS SKAWDALGPP GSRHPEHAFY EFTFRRFFDD NGYPFRCPKP AAADTGTEAE
QPAAGAPTPG AQAGGCQPVY V
//
