ID A0A2Y9SX50_PHYMC Unreviewed; 553 AA.
AC A0A2Y9SX50;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Heterochromatin protein 1-binding protein 3 {ECO:0000256|ARBA:ARBA00019297};
GN Name=HP1BP3 {ECO:0000313|RefSeq:XP_007120691.1,
GN ECO:0000313|RefSeq:XP_023981114.1, ECO:0000313|RefSeq:XP_023981115.1,
GN ECO:0000313|RefSeq:XP_023981116.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023981115.1};
RN [1] {ECO:0000313|RefSeq:XP_007120691.1, ECO:0000313|RefSeq:XP_023981114.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007120691.1,
RC ECO:0000313|RefSeq:XP_023981114.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_007120691.1; XM_007120629.4.
DR RefSeq; XP_007120692.1; XM_007120630.1.
DR RefSeq; XP_007120693.1; XM_007120631.1.
DR RefSeq; XP_023981114.1; XM_024125346.3.
DR RefSeq; XP_023981115.1; XM_024125347.3.
DR RefSeq; XP_023981116.1; XM_024125348.3.
DR STRING; 9755.ENSPCTP00005018348; -.
DR Ensembl; ENSPCTT00005020216; ENSPCTP00005018348; ENSPCTG00005013029.
DR GeneID; 102995224; -.
DR KEGG; pcad:102995224; -.
DR CTD; 50809; -.
DR OrthoDB; 3029985at2759; -.
DR Proteomes; UP000248484; Chromosome 3.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0031491; F:nucleosome binding; IEA:Ensembl.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0070828; P:heterochromatin organization; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0097298; P:regulation of nucleus size; IEA:Ensembl.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR15832:SF1; HETEROCHROMATIN PROTEIN 1-BINDING PROTEIN 3; 1.
DR PANTHER; PTHR15832; SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG; 1.
DR Pfam; PF00538; Linker_histone; 3.
DR SMART; SM00526; H15; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS51504; H15; 3.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 157..232
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT DOMAIN 255..330
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT DOMAIN 337..413
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT REGION 29..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..79
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..447
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 61203 MW; D904822F13AA890D CRC64;
MATDTSQGEL VHPKALPLIV GAQLIHADKL GEKVEDNTMP IRRAVNSTRE TPPKSKLAEG
EEEKPEPDVS SEESVSTVEE QENETPPATS SETEQPKGQP ENEEKEENKP SEETKKDEKD
QSKEKEKKVK KTIPSWATLS ASQLARAQKQ TPMASSPRPK MDAILTEAIK ACFQKSGASV
VAIRKYIIHK YPSLELERRG YLLKQALKRE LNRGVIKQVK GKGASGSFIV VQKSRKTPQK
SRNRKNRSSA VDPEPQVKLE DILPLAFTRL CEPKEASYSL IRKYVSQYYP KLRVDIRPQL
LKNALQRAVE RGQLEQITGK GASGTFQLKK SGEKPLLGGS LMEYAILSAI AAMNEPKTCS
TTALKKYVLE NHPGTNSNYQ MHLLKKTLQR CEKNGWMEQI SGKGFSGTFQ LCFPYYPSPG
VLFPKKEPDD SKDEAEDEDE SSEEDSEDEE PPPKRRLQKK TPAKSPGKAA SMKQRGSKPA
PKVPAAQRGK ARPLPKKAPP KAKTPAKKAR PSPPVIKKPS GSSSKKPAAS VRKEVKLPGK
GKSTMKKSFK AKK
//
