ID A0A2Y9SYP4_PHYMC Unreviewed; 2856 AA.
AC A0A2Y9SYP4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Lipopolysaccharide-responsive and beige-like anchor protein isoform X6 {ECO:0000313|RefSeq:XP_023982442.1};
GN Name=LRBA {ECO:0000313|RefSeq:XP_023982442.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023982442.1};
RN [1] {ECO:0000313|RefSeq:XP_023982442.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023982442.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_023982442.1; XM_024126674.3.
DR STRING; 9755.ENSPCTP00005003433; -.
DR Ensembl; ENSPCTT00005003777; ENSPCTP00005003433; ENSPCTG00005002441.
DR KEGG; pcad:102979012; -.
DR Proteomes; UP000248484; Chromosome 7.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF64; LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2066..2174
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2193..2482
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2768..2809
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1158..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1262..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1559..1637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1763..1783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..1028
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1177..1207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1568..1600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2856 AA; 317639 MW; A9FF16EEC1A7E2C1 CRC64;
MASEDSIAPS PPPTGDDGGG GGKGEETPAE GGALSLKPGL PIRGIRMKFA VLTGLIEVGE
VSNRDIVETV FNLLVGGQFD LEMNFIIQEG ESIICMVDLL EKCDVTCQAE VWSMFTAILK
KSIRNLQVCT EVGLVEKVLG KIEKVDNMIA DLLVDMLGVL ASYNLTVREL KLFFSKLQGD
KGQWPPHAGK LLSVLKHMPQ KYGPDAFFNF PGKSAAAIAL PPIAKWPYQN GFTFHTWLRM
DPVNNINVDK DKPYLYCFRT SKGLGYSAHF VGGCLIITSV KSKGKGFQHC VKFDFKPQKW
YMVTIVHIYN RWKNSELRCY VNGELASYGE ITWFVNTSDT FDKCFLGSSE TADANRVFCG
QMTAVYLFSE ALNAAQIFAI YQLGLGYKGT FKFKAESDLF LVEHHKLLLY DGKLSSAIAF
TYNPRATDAQ LCLESSPKDN PSIFVHSPHA LMLQDVKAVL THSIQSAMHS IGGVQVLFPL
FAQLDYRQYL SDEVDLTICS TLLAFIMELL KNSVAMQEQM LACKGFLVIG YSLEKSSKSH
VSRAVLELCL AFSKYLSNLQ NGMPLLKQLC DHILLNPAIW IHTPAKVQLT LYTYLSTEFI
GTVNIYNAIR RVGTVLLIMH TLKYYYWAVN PQDRSGITPK GLDGPRPNQK EMLSLRAFLL
MFIKQLVMKD SGVKEDELQA ILNYLLTMHE DDNLMDVLQL LVALMSEHPN SMIPAFDQRN
GLRVIYKLMA SKSEGIRVQA LKAMGYFLKH LAPKRKAEVM LGHGLFSLLT ERLMLQTNLI
TMTTYNVLFE ILIEQICTQV IHKQHPDPDS SVKIQNPQIL KVIATLLRNS PQCPESMEVR
RAFLSDMIKL FNNSRENRRS LLQCSVWQEW MLSLCYFNPK NSDEQKITEM VYAIFRILLY
HAIKYEWGGW RVWVDTLSIT HSKVTFEIHK ENLANIFREH QGKVDEEIGQ CSSSPIQAVS
GTSRDVNVSV GSQQLDTKDS PPSSHITRTS DEKSSIGKTS SVESASNVEL QTHNTSNEER
TTVQENQGLL DEVPLEETLI NETINSESLE GSSDIIEAVT VSSDSFKTTG KDIMTVNEVT
ASISSPSEED VSEVPELLDK SVVEEEEDDD YVELKVESIP TEEASLPTEL QDNSLSPAAS
EASERMDMFS NDHKLIFQEE EPVSKKQTDT ETRDPKDSAV LTMTASGSSA TSPGTTASQT
TVQSDVGQML EVGEKTNLTG ETKLHSDSNS SIFESPTTSE QKIAKLDVSS VATDTERLEL
KATTNMEASQ RHQPVLEMSR QQEQPGQGTA PDAVNGQRRD SRSMFRIPEF KWSQVHQRLL
TDLLFSIETD IQMWRSHSTK TVMDFVNSSD NVIFVHNTIH LISQVMDNMV MACGGILPLL
SAATSATHEL ENIEPTQGLS IEASVTFLQR LISLVDVLIF ASSLGFTEIE AEKNMSSGGI
LRQCLRMVCA VAVRNCLECQ QHSQLKTKGK AGKVQKTAHS LIPMGKSAAK SPVDIVTGGI
SPVRDFDRLL QDMDINRLRA VVFRDIEDSK QAQFLALAVV YFISVLMVSK YRDILEPQNE
RHSQSFKETG SESGNLSLPD IENSPAAFSP LTPASVEESE SASSARRRDS GIGEEMATGL
GSNVDVAPPV APPSVSAGPD AISEVLCTLS SEVSKSQETK SDGENELDNK AAPSVPVSKN
INVKDILRSL VNIPGDGVTV DPALLPPACL GALGDLSVEQ PVQFRSFDRS VIVATKKSAV
LPSTLTSIPT NAVSVVSSVD SAQASDVGGE SPGGRSSNAK LPAVPTVGSV SQDQVSNMSI
TERLEHALEK AAPLLREIFV DFAPFLSRTL LGSHGQELLI EGTSLVCMKS SSSVVELVML
LCSQEWQNSI QKNAGLAFIE LVNEGRLLSQ TMKDHLVRVA NEAEFILSRQ RAEDIHRHAE
FESLCAQYSA DRREDEKMCD HLIRAAKYRD HVTATQLIQK IINILTDKHG AWGNSAVSRP
REFWRLDYWE DDLRRRRRFV RNPLGSTHPE ATLKTAVEHA ADEDILAKGK QSIKSKALGN
QNSENEILLE GDDDTLSSVD EKDLENLTGP VSLSTPAQLV APSVVVKGTL SVTSSELYFE
VDEEDPNFKK IDPKILAYTE GLHGKWLFTE IRSIFSRRYL LQNTALEIFM ANRVAIMFNF
PDPATVKKVV NYLPRVGIGT SFGLLQTRRI SLASPRQLFK ASNMTQRWQH REISNFEYLM
FLNTIAGRSY NDLNQYPVFP WVITNYESEE LDLTLPSNFR DLSKPIGALN PKRAAFFAER
YESWEDDQVP KFHYGTHYST ASFVLAWLLR IEPFTTSFLN LQGGKFDHAD RTFSSISRAW
RNSQRDTSDI KELIPEFYYL PEMFVNFNNY NLGVMDDGTV VSDVELPPWA KTSEEFVRIN
RLALESEFVS CQLHQWIDLI FGYKQQGPEA VRALNVFYYL TYEGAVNLNS ITDPVLREAV
EAQIRSFGQT PSQLLLEPHP PRGSAMQASP LMFTDQAQQD VIMVLKFPSN SPVTHVAANT
QPGLATPAVI TVTANRLFAV NKWHNLPAHQ GAVQDQPCQL PVEIDPLIAS NTGMHRRQIT
DLLDQSIQVH SQCFVITSDN RYVLLCGFWD KSFRVYSADT GKLIQVVFGH WDVVTCLTRS
ESYIGGNCYI LSGSRDATLL LWYWNGKSSG IGDNPGSETT TPRAILTGHD SEITCAVVCA
ELGLVLSGSK GGPCLIHSMN GDLLRTLEGP ENCLKPKLIQ ASREGHCVIF YENGFFCTFS
VNGKLQATME TDDNIRAIQL SRDGQYLLTG GDNGVVMVWQ VSDLKQLFAY PGCDAGIRAM
ALSYDQRCII SGMASGSIVL FYNDFNRWHH EYQTRY
//
